Chemoselective synthesis of tetrasubstituted furans via intramolecular Wittig reactions: Mechanism and theoretical analysis

Yu Ting Lee, Yen Te Lee, Chia Jui Lee, Chia Ning Sheu, Bo Yu Lin, Jeng Han Wang, Wenwei Lin

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19 引文 斯高帕斯(Scopus)

摘要

An efficient synthesis of tetrasubstituted furans was achieved from the corresponding α,β-unsaturated ketone derivatives, acid chlorides, and Bu3P in the presence of Et3N via a chemoselective intramolecular Wittig reaction as the key step. The presence of an additional electron-withdrawing group in the α-position of Michael acceptors controlled the chemoselectivities of presumable phosphorus ylides in the intramolecular Wittig reactions, and their mechanisms were also investigated by DFT calculations.

原文英語
頁(從 - 到)5156-5161
頁數6
期刊Organic and Biomolecular Chemistry
11
發行號31
DOIs
出版狀態已發佈 - 2013 八月 21

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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