摘要
The reactions of 6-cyano-1,3-dimethyluracil have been studied as chemical models to illustrate the mechanism for the transformation of 6-cyanouridine 5′-monophosphate (6-CN-UMP) to barbiturate ribonucleoside 5′-monophosphate (BMP) catalyzed by orotidine 5′-monophosphate decarboxylase (ODCase). The results suggest that the Asp residue in the ODCase active site plays the role of a general base in the transformation.
原文 | 英語 |
---|---|
頁(從 - 到) | 4821-4823 |
頁數 | 3 |
期刊 | Chemical Communications |
卷 | 46 |
發行號 | 26 |
DOIs | |
出版狀態 | 已發佈 - 2010 7月 14 |
ASJC Scopus subject areas
- 催化
- 電子、光磁材料
- 陶瓷和複合材料
- 一般化學
- 表面、塗料和薄膜
- 金屬和合金
- 材料化學