Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase

Tun Cheng Chien; Cheng Hung Jen; Yuen Jen Wu; Chen Chieh Liao

doi:10.1093/nass/nrn150

Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase

Tun Cheng Chien
, Cheng Hung Jen
, Yuen Jen Wu
, Chen Chieh Liao

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

1 引文斯高帕斯（Scopus）

摘要

Orotidine 5'-monophosphate decarboxylase (ODCase) catalyzes an unprecedented transformation of 6- cyanouridine 5'-monophosphate (6-CN-UMP) into barbiturate nucleoside 5'-monophosphate (6-hydroxyuridine 5'-monophosphate, BMP). The reactions of 6- cyano-1,3-dimethyluracil toward various nucleophilic conditions have been studied as chemical models in order to understand the possible mechanism for the ODCase-catalyzed transformation of 6-CN-UMP.

原文	英語
頁（從 - 到）	297-298
頁數	2
期刊	Nucleic acids symposium series (2004)
發行號	52
DOIs	https://doi.org/10.1093/nass/nrn150
出版狀態	已發佈 - 2008

ASJC Scopus subject areas

一般醫學

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10.1093/nass/nrn150

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abstract = "Orotidine 5'-monophosphate decarboxylase (ODCase) catalyzes an unprecedented transformation of 6- cyanouridine 5'-monophosphate (6-CN-UMP) into barbiturate nucleoside 5'-monophosphate (6-hydroxyuridine 5'-monophosphate, BMP). The reactions of 6- cyano-1,3-dimethyluracil toward various nucleophilic conditions have been studied as chemical models in order to understand the possible mechanism for the ODCase-catalyzed transformation of 6-CN-UMP.",

author = "Chien, \{Tun Cheng\} and Jen, \{Cheng Hung\} and Wu, \{Yuen Jen\} and Liao, \{Chen Chieh\}",

year = "2008",

doi = "10.1093/nass/nrn150",

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journal = "Nucleic acids symposium series (2004)",

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T1 - Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase

AU - Chien, Tun Cheng

AU - Jen, Cheng Hung

AU - Wu, Yuen Jen

AU - Liao, Chen Chieh

PY - 2008

Y1 - 2008

N2 - Orotidine 5'-monophosphate decarboxylase (ODCase) catalyzes an unprecedented transformation of 6- cyanouridine 5'-monophosphate (6-CN-UMP) into barbiturate nucleoside 5'-monophosphate (6-hydroxyuridine 5'-monophosphate, BMP). The reactions of 6- cyano-1,3-dimethyluracil toward various nucleophilic conditions have been studied as chemical models in order to understand the possible mechanism for the ODCase-catalyzed transformation of 6-CN-UMP.

AB - Orotidine 5'-monophosphate decarboxylase (ODCase) catalyzes an unprecedented transformation of 6- cyanouridine 5'-monophosphate (6-CN-UMP) into barbiturate nucleoside 5'-monophosphate (6-hydroxyuridine 5'-monophosphate, BMP). The reactions of 6- cyano-1,3-dimethyluracil toward various nucleophilic conditions have been studied as chemical models in order to understand the possible mechanism for the ODCase-catalyzed transformation of 6-CN-UMP.

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UR - https://www.scopus.com/pages/publications/78649428331#tab=citedBy

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SN - 1746-8272

SP - 297

EP - 298

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

IS - 52

ER -

Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase

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