Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

Yuen Jen Wu, Chen Chieh Liao, Cheng Hung Jen, Yu Chiao Shih, Tun Cheng Chien

研究成果: 雜誌貢獻期刊論文同行評審

3 引文 斯高帕斯(Scopus)

摘要

The reactions of 6-cyano-1,3-dimethyluracil have been studied as chemical models to illustrate the mechanism for the transformation of 6-cyanouridine 5′-monophosphate (6-CN-UMP) to barbiturate ribonucleoside 5′-monophosphate (BMP) catalyzed by orotidine 5′-monophosphate decarboxylase (ODCase). The results suggest that the Asp residue in the ODCase active site plays the role of a general base in the transformation.

原文英語
頁(從 - 到)4821-4823
頁數3
期刊Chemical Communications
46
發行號26
DOIs
出版狀態已發佈 - 2010 七月 14

ASJC Scopus subject areas

  • 催化
  • 電子、光磁材料
  • 陶瓷和複合材料
  • 化學 (全部)
  • 表面、塗料和薄膜
  • 金屬和合金
  • 材料化學

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