Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase.

Tun Cheng Chien, Cheng Hung Jen, Yuen Jen Wu, Chen Chieh Liao

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

摘要

Orotidine 5'-monophosphate decarboxylase (ODCase) catalyzes an unprecedented transformation of 6- cyanouridine 5'-monophosphate (6-CN-UMP) into barbiturate nucleoside 5'-monophosphate (6-hydroxyuridine 5'-monophosphate, BMP). The reactions of 6- cyano-1,3-dimethyluracil toward various nucleophilic conditions have been studied as chemical models in order to understand the possible mechanism for the ODCase-catalyzed transformation of 6-CN-UMP.

原文英語
頁(從 - 到)297-298
頁數2
期刊Nucleic acids symposium series (2004)
發行號52
出版狀態已發佈 - 2008 十二月 1

    指紋

ASJC Scopus subject areas

  • Medicine(all)

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