Bumetanide administration attenuated traumatic brain injury through IL-1 overexpression

Kwok Tung Lu, Chang Yen Wu, Hao Han Yen, Jeng Hsiung F. Peng, Chi Ling Wang, Yi Ling Yang

研究成果: 雜誌貢獻文章

33 引文 斯高帕斯(Scopus)

摘要

Objective: To examine the effects of administration of bumetanide, a specific NKCC1 inhibitor, on traumatic brain injury (TBI)-induced interleukin-1 (IL-1) expression. Methods: TBI model was induced by the calibrated weight drop device (450 g in weight, 2.0 m in height) in adult rats based on procedures previously reported. One hundred and sixty Wistar rats were divided into sham-control group and experimental group for time course works of TBI. The expression of IL-1β brain edema and neuronal damage were determined in these animals after TBI. Results: We found that both mRNA and protein of IL-1β were up-regulated in the hippocampus 3-24 hours after TBI. Animals displayed severe brain edema and neuron damage after TBI. Bumetanide (15 mg/kg), a specific Na+ -K+ -2Cl- cotransporter inhibitor, significantly attenuated the TBI-induced neuronal damage by IL-1β overexpression. The present stuay suggests that administration of bumetanide could significantly decreased TBI-induced inflammatory response and neuronal damage.

原文英語
頁(從 - 到)404-409
頁數6
期刊Neurological Research
29
發行號4
DOIs
出版狀態已發佈 - 2007 六月 1

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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