The main target in this research was to assist elementary schools building a smart classroom. To let students learn in the smart classroom, four points were underlined as follows: (1) developing the inquiry-based nature science learning materials, quiz, and model; (2) designing digital learning system and tools; (3) doing teacher and student training; and (4) planning the learning environment. There are 18 schools, 22 teachers, and 1355 fourth-grade students in Taipei City and New Taipei City joined this project. The research guides the concept of standard operating procedure, which means everything has its standard operating procedure to ensure the operation effective and quality; it is also a benefit for large-scale promotion. The result showed that students’ science learning performance has enhanced prominently. The inquiry-based nature science courses help student understand the main points of science question and finally construct the completed scientific concept and knowledge.