2-(Acylmethylene)pyrrolidine derivatives were synthesized via intermolecular decarbonylative Mannich reaction from various methyl ketones and 1-alkyl-1-pyrroliniums, generated in situ from 1-alkylprolines. This approach mimics the biosynthetic pathway and provides a direct access to a series of 2-(acylmethylene)pyrrolidine alkaloids, including hygrine, N-methylruspolinone, dehydrodarlinine, and ruspolinone.
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指紋深入研究「Biomimetic Approach toward the Total Synthesis of rac-2-(Acylmethylene)pyrrolidine Alkaloids」主題。共同形成了獨特的指紋。
Shih, Y. (Creator), Tsai, P. (Creator), Hsu, C. (Creator), Chang, C. (Creator), Jhong, Y. (Creator), Chen, Y. (Creator) & Chien, T. (Creator), Unknown Publisher, 2015