Biomimetic Approach toward the Total Synthesis of rac-2-(Acylmethylene)pyrrolidine Alkaloids

Yu Chiao Shih, Pei Hua Tsai, Chia Chun Hsu, Chih Wei Chang, Yuandong Jhong, Yun Chung Chen, Tun Cheng Chien

研究成果: 雜誌貢獻期刊論文同行評審

10 引文 斯高帕斯(Scopus)

摘要

2-(Acylmethylene)pyrrolidine derivatives were synthesized via intermolecular decarbonylative Mannich reaction from various methyl ketones and 1-alkyl-1-pyrroliniums, generated in situ from 1-alkylprolines. This approach mimics the biosynthetic pathway and provides a direct access to a series of 2-(acylmethylene)pyrrolidine alkaloids, including hygrine, N-methylruspolinone, dehydrodarlinine, and ruspolinone.

原文英語
頁(從 - 到)6669-6678
頁數10
期刊Journal of Organic Chemistry
80
發行號13
DOIs
出版狀態已發佈 - 2015 七月 2

ASJC Scopus subject areas

  • Organic Chemistry

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