Biological and clinical significance of the AGE-RAGE axis in the aggressiveness and prognosis of prostate cancer

Shih Hong Khoo, Pei Ru Wu, Kun Tu Yeh, Shih Lan Hsu, Chi Hao Wu*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

Dietary factors and chronic hyperglycemia are linked to the formation of advanced glycation end products (AGEs) and prostate cancer (PCa) risk. The activation of the receptor for AGEs (RAGE) acts as a bridge between various RAGE ligands and certain malignancies. This study showed that the interaction of AGEs and RAGE promoted PCa cell proliferation, invasion, and autophagy-mediated survival in response to chemotherapeutic agents. RAGE-overexpressed PCa cells underwent epithelialemesenchymal transition and showed increased cancer stem cell-like properties. In mouse xenograft models, RAGE-overexpressed cells showed more substantial tumorigenic capacity than parental cells, whereas RAGE knockdown decreased tumorigenicity. The clinical data validated a positive correlation between high AGE and RAGE expressions with poor clinical outcomes. Our findings suggest that the AGE-RAGE axis facilitates PCa progression and aggressiveness. Prostatic AGEs and RAGE expression levels are associated with PCa prognosis. Adherence to a reduced-AGE diet and targeting RAGE are potential approaches to complement and synergize with the current PCa therapies.

原文英語
頁(從 - 到)664-682
頁數19
期刊Journal of Food and Drug Analysis
31
發行號4
DOIs
出版狀態已發佈 - 2023

ASJC Scopus subject areas

  • 食品科學
  • 藥理

指紋

深入研究「Biological and clinical significance of the AGE-RAGE axis in the aggressiveness and prognosis of prostate cancer」主題。共同形成了獨特的指紋。

引用此