Biofunctionalized magnetic nanoparticles for in vitro labeling and in vivo locating specific biomolecules

C. C. Wu; L. Y. Lin; L. C. Lin; H. C. Huang; Y. F. Yang; Y. B. Liu; M. C. Tsai; Y. L. Gao; W. C. Wang; S. W. Hung; S. Y. Yang; H. E. Horng; H. C. Yang; W. Y.I. Tseng; H. I. Yeh; C. F. Hsuan; T. L. Lee; W. K. Tseng

doi:10.1063/1.2907486

Biofunctionalized magnetic nanoparticles for in vitro labeling and in vivo locating specific biomolecules

C. C. Wu, L. Y. Lin, L. C. Lin, H. C. Huang, Y. F. Yang, Y. B. Liu, M. C. Tsai, Y. L. Gao, W. C. Wang, S. W. Hung, S. Y. Yang, H. E. Horng, H. C. Yang, W. Y.I. Tseng, H. I. Yeh, C. F. Hsuan, T. L. Lee, W. K. Tseng

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

20 引文斯高帕斯（Scopus）

摘要

In this work, we developed processes to biofunctionalize magnetic nanoparticles dispersed in phosphate buffer saline solution. For future clinical utility, magnetic nanoparticles were biofunctionalized with anti-vascular cell adhesion molecule-1 (VCAM-1) to label the VCAM-1 molecule, which served as an indicator for the lesions prone to vulnerable atherosclerotic plaque formation. The biofunctionalized magnetic nanoparticles were used to magnetically label, in vitro, cells expressing VCAM-1, as well as to locate the vulnerable aortic lesions of hypercholesterolemic rabbits with the aid of magnetic resonance imaging. In addition to demonstrating the feasibility of using biofunctionalized magnetic nanoparticles for biomolecule assays, the relevant physical mechanisms are discussed.

原文	英語
文章編號	142504
期刊	Applied Physics Letters
卷	92
發行號	14
DOIs	https://doi.org/10.1063/1.2907486
出版狀態	已發佈 - 2008
對外發佈	是

ASJC Scopus subject areas

物理與天文學（雜項）

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10.1063/1.2907486

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Wu, C. C., Lin, L. Y., Lin, L. C., Huang, H. C., Yang, Y. F., Liu, Y. B., Tsai, M. C., Gao, Y. L., Wang, W. C., Hung, S. W., Yang, S. Y., Horng, H. E., Yang, H. C., Tseng, W. Y. I., Yeh, H. I., Hsuan, C. F., Lee, T. L., & Tseng, W. K. (2008). Biofunctionalized magnetic nanoparticles for in vitro labeling and in vivo locating specific biomolecules. Applied Physics Letters, 92(14), [142504]. https://doi.org/10.1063/1.2907486

Biofunctionalized magnetic nanoparticles for in vitro labeling and in vivo locating specific biomolecules. / Wu, C. C.; Lin, L. Y.; Lin, L. C.; Huang, H. C.; Yang, Y. F.; Liu, Y. B.; Tsai, M. C.; Gao, Y. L.; Wang, W. C.; Hung, S. W.; Yang, S. Y.; Horng, H. E.; Yang, H. C.; Tseng, W. Y.I.; Yeh, H. I.; Hsuan, C. F.; Lee, T. L.; Tseng, W. K.

於: Applied Physics Letters, 卷 92, 編號 14, 142504, 2008.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

Wu, CC, Lin, LY, Lin, LC, Huang, HC, Yang, YF, Liu, YB, Tsai, MC, Gao, YL, Wang, WC, Hung, SW, Yang, SY, Horng, HE, Yang, HC, Tseng, WYI, Yeh, HI, Hsuan, CF, Lee, TL & Tseng, WK 2008, 'Biofunctionalized magnetic nanoparticles for in vitro labeling and in vivo locating specific biomolecules', Applied Physics Letters, 卷 92, 編號 14, 142504. https://doi.org/10.1063/1.2907486

Wu, C. C. ; Lin, L. Y. ; Lin, L. C. ; Huang, H. C. ; Yang, Y. F. ; Liu, Y. B. ; Tsai, M. C. ; Gao, Y. L. ; Wang, W. C. ; Hung, S. W. ; Yang, S. Y. ; Horng, H. E. ; Yang, H. C. ; Tseng, W. Y.I. ; Yeh, H. I. ; Hsuan, C. F. ; Lee, T. L. ; Tseng, W. K. / Biofunctionalized magnetic nanoparticles for in vitro labeling and in vivo locating specific biomolecules. 於: Applied Physics Letters. 2008 ; 卷 92, 編號 14.

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title = "Biofunctionalized magnetic nanoparticles for in vitro labeling and in vivo locating specific biomolecules",

abstract = "In this work, we developed processes to biofunctionalize magnetic nanoparticles dispersed in phosphate buffer saline solution. For future clinical utility, magnetic nanoparticles were biofunctionalized with anti-vascular cell adhesion molecule-1 (VCAM-1) to label the VCAM-1 molecule, which served as an indicator for the lesions prone to vulnerable atherosclerotic plaque formation. The biofunctionalized magnetic nanoparticles were used to magnetically label, in vitro, cells expressing VCAM-1, as well as to locate the vulnerable aortic lesions of hypercholesterolemic rabbits with the aid of magnetic resonance imaging. In addition to demonstrating the feasibility of using biofunctionalized magnetic nanoparticles for biomolecule assays, the relevant physical mechanisms are discussed.",

author = "Wu, {C. C.} and Lin, {L. Y.} and Lin, {L. C.} and Huang, {H. C.} and Yang, {Y. F.} and Liu, {Y. B.} and Tsai, {M. C.} and Gao, {Y. L.} and Wang, {W. C.} and Hung, {S. W.} and Yang, {S. Y.} and Horng, {H. E.} and Yang, {H. C.} and Tseng, {W. Y.I.} and Yeh, {H. I.} and Hsuan, {C. F.} and Lee, {T. L.} and Tseng, {W. K.}",

note = "Funding Information: This work is supported by the National Science Council of Taiwan under Grant Nos. 95-2120-M-003-001, 95-2112-M-003-017-MY2, 95-2112-M-003-019, 95-2221-E-212-054-MY3, 95-2752-M-002-016-PAE, and 96-2314-B-002-150-MY3.",

year = "2008",

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journal = "Applied Physics Letters",

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AU - Wu, C. C.

AU - Lin, L. Y.

AU - Lin, L. C.

AU - Huang, H. C.

AU - Yang, Y. F.

AU - Liu, Y. B.

AU - Tsai, M. C.

AU - Gao, Y. L.

AU - Wang, W. C.

AU - Hung, S. W.

AU - Yang, S. Y.

AU - Horng, H. E.

AU - Yang, H. C.

AU - Tseng, W. Y.I.

AU - Yeh, H. I.

AU - Hsuan, C. F.

AU - Lee, T. L.

AU - Tseng, W. K.

N1 - Funding Information: This work is supported by the National Science Council of Taiwan under Grant Nos. 95-2120-M-003-001, 95-2112-M-003-017-MY2, 95-2112-M-003-019, 95-2221-E-212-054-MY3, 95-2752-M-002-016-PAE, and 96-2314-B-002-150-MY3.

PY - 2008

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AB - In this work, we developed processes to biofunctionalize magnetic nanoparticles dispersed in phosphate buffer saline solution. For future clinical utility, magnetic nanoparticles were biofunctionalized with anti-vascular cell adhesion molecule-1 (VCAM-1) to label the VCAM-1 molecule, which served as an indicator for the lesions prone to vulnerable atherosclerotic plaque formation. The biofunctionalized magnetic nanoparticles were used to magnetically label, in vitro, cells expressing VCAM-1, as well as to locate the vulnerable aortic lesions of hypercholesterolemic rabbits with the aid of magnetic resonance imaging. In addition to demonstrating the feasibility of using biofunctionalized magnetic nanoparticles for biomolecule assays, the relevant physical mechanisms are discussed.

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Biofunctionalized magnetic nanoparticles for in vitro labeling and in vivo locating specific biomolecules

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