TY - JOUR
T1 - Beta2-adrenergic agonist use and the risk of multiple sclerosis
T2 - A total population-based case-control study
AU - Tsai, Ching Piao
AU - Lin, Feng Cheng
AU - Lee, Charles Tzu Chi
N1 - Publisher Copyright:
© The Author(s) 2014.
PY - 2014/10/11
Y1 - 2014/10/11
N2 - Objective: The aim of this study was to investigate whether the use of fenoterol, a beta2-adrenergic agonist, was associated with multiple sclerosis (MS) risk by conducting a total population-based case-control study in Taiwan. Methods: A total of 578 patients with newly diagnosed MS who had a severely disabling disease (SDD) certificate between January 1, 2002 and December 1, 2008 comprised the case group. These cases were compared with 2890 gender-, age-, residence-, and insurance premium-matched controls. Fenoterol use was analyzed using a conditional logistic regression model that controlled for asthma, chronic obstructive pulmonary disease (COPD), salbutamol and steroid use. Results: Compared with the group of people who did not use fenoterol, the adjusted odds ratios were 0.67 (95% confidence interval (CI) = 0.48-0.93, p = 0.016) for the group prescribed fenoterol below 2.25 cumulative defined daily dose (cDDD) and 0.49 (95% CI = 0.33-0.71, p 0.001) for the group with a cumulative fenoterol use of more than 2.25 cDDD. The dose-response relationship was similar within the non-asthma patients. The associations were similar between males and females, but differences between age groups were observed. Conclusions: The results of this study suggest that fenoterol use may reduce the risk of MS.
AB - Objective: The aim of this study was to investigate whether the use of fenoterol, a beta2-adrenergic agonist, was associated with multiple sclerosis (MS) risk by conducting a total population-based case-control study in Taiwan. Methods: A total of 578 patients with newly diagnosed MS who had a severely disabling disease (SDD) certificate between January 1, 2002 and December 1, 2008 comprised the case group. These cases were compared with 2890 gender-, age-, residence-, and insurance premium-matched controls. Fenoterol use was analyzed using a conditional logistic regression model that controlled for asthma, chronic obstructive pulmonary disease (COPD), salbutamol and steroid use. Results: Compared with the group of people who did not use fenoterol, the adjusted odds ratios were 0.67 (95% confidence interval (CI) = 0.48-0.93, p = 0.016) for the group prescribed fenoterol below 2.25 cumulative defined daily dose (cDDD) and 0.49 (95% CI = 0.33-0.71, p 0.001) for the group with a cumulative fenoterol use of more than 2.25 cDDD. The dose-response relationship was similar within the non-asthma patients. The associations were similar between males and females, but differences between age groups were observed. Conclusions: The results of this study suggest that fenoterol use may reduce the risk of MS.
KW - Multiple sclerosis
KW - case-control study
KW - fenoterol
UR - http://www.scopus.com/inward/record.url?scp=84910155983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84910155983&partnerID=8YFLogxK
U2 - 10.1177/1352458514528758
DO - 10.1177/1352458514528758
M3 - Article
C2 - 24732071
AN - SCOPUS:84910155983
SN - 1352-4585
VL - 20
SP - 1593
EP - 1601
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 12
ER -