Base-catalyzed conjugate addition of thiols to indolyl acrylic acids and in situ decarboxylation: An expedient synthesis of functionalized 3-(1-thio)ethyl-1H-indoles

Shijay Gao, Chi Tseng, B. Rama Raju, Chen Hsuan Tsai, Ching Fa Yao

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

摘要

A one-pot, two-step method for the synthesis of 3-(1-thio)ethyl- 1H-indoles is described herein. This simple procedure in-volves the Michael addition of thiols to 3-indoleacrylic acids fol-lowed by in situ decarboxylation of the Michael adduct in the presence of a catalytic amount of K2CO 3 in DMF at 100 °C. The method was found to be fairly general with various thiols and dif-ferent 3-indoleacrylic acids.

原文英語
頁(從 - 到)3201-3205
頁數5
期刊Synlett
發行號19
DOIs
出版狀態已發佈 - 2009 十二月 21

    指紋

ASJC Scopus subject areas

  • Organic Chemistry

引用此