Base-Catalysed (4+2)-Annulation Between 2-Nitrobenzofurans and N-Alkoxyacrylamides: Synthesis of [3,2-b]Benzofuropyridinones

Gunda Ananda Rao, Ramani Gurubrahamam*, Kwunmin Chen*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

An efficient protocol for base-catalysed (4+2) annulation between 2-nitrobenzofuran and N-alkoxyacrylamide was developed. The corresponding 1-alkoxy-3,4-dihydrobenzofuro[3,2-b]pyridin-2(1H)-ones were obtained in high to excellent yields by organic base catalysis. In addition, a dearomative nitrotetrahydrobenzofuro[3,2-b]pyridin-2(3H)-ones were also obtained in high yields in the presence of an inorganic base. The advantages of this methodology include easily accessible starting materials, simple operational procedures, broad substrate scope, and synthetically useful yields at milder reaction conditions.

原文英語
文章編號e202200657
期刊European Journal of Organic Chemistry
2022
發行號30
DOIs
出版狀態已發佈 - 2022 8月 12

ASJC Scopus subject areas

  • 物理與理論化學
  • 有機化學

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