摘要
The asymmetric conjugate addition of arylboronic acids to N-phthalimidodehydroalanine 1i catalyzed by Rh(I)/L1a enables the facile preparation of chiral functionalized phenylalanines. The reaction proceeds by a conjugate addition and enantioselective protonation cascade, affording a rhodium enolate that undergoes re-face protonation. The reaction tolerates various arylboronic acids and can be used in the gram-scale synthesis of (S)-phenylalanine hydrochloride, demonstrating the reaction scope and the synthetic feasibility of the process.
原文 | 英語 |
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頁(從 - 到) | 9468-9472 |
頁數 | 5 |
期刊 | Organic Letters |
卷 | 21 |
發行號 | 23 |
DOIs | |
出版狀態 | 已發佈 - 2019 12月 6 |
ASJC Scopus subject areas
- 生物化學
- 物理與理論化學
- 有機化學
指紋
深入研究「Asymmetric Synthesis of Functionalized Phenylalanine Derivatives via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade」主題。共同形成了獨特的指紋。資料集
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CCDC 1959338: Experimental Crystal Structure Determination
Jian, J. (Contributor), Zeng, H. (Contributor), Kuo, T. (Contributor), Wu, P. (Contributor) & Wu, H. (Contributor), Unknown Publisher, 2019
DOI: 10.5517/ccdc.csd.cc23rvg6, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc23rvg6&sid=DataCite
資料集: Dataset