@article{61fe8ab03c6b4cbcad71ac9dd20e88cf,
title = "Asymmetric Synthesis of Functionalized Phenylalanine Derivatives via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade",
abstract = "The asymmetric conjugate addition of arylboronic acids to N-phthalimidodehydroalanine 1i catalyzed by Rh(I)/L1a enables the facile preparation of chiral functionalized phenylalanines. The reaction proceeds by a conjugate addition and enantioselective protonation cascade, affording a rhodium enolate that undergoes re-face protonation. The reaction tolerates various arylboronic acids and can be used in the gram-scale synthesis of (S)-phenylalanine hydrochloride, demonstrating the reaction scope and the synthetic feasibility of the process.",
author = "Jian, {Jia Hong} and Zeng, {Hao Wei} and Kuo, {Ting Shen} and Wu, {Ping Yu} and Wu, {Hsyueh Liang}",
note = "Funding Information: Financial support from the Ministry of Science and Technology of the Republic of China (104-2628-M-003-001-MY3 and 107-2113-M-003-014-MY3) is gratefully acknowledged. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",
year = "2019",
month = dec,
day = "6",
doi = "10.1021/acs.orglett.9b03666",
language = "English",
volume = "21",
pages = "9468--9472",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "23",
}