The asymmetric conjugate addition of arylboronic acids to N-phthalimidodehydroalanine 1i catalyzed by Rh(I)/L1a enables the facile preparation of chiral functionalized phenylalanines. The reaction proceeds by a conjugate addition and enantioselective protonation cascade, affording a rhodium enolate that undergoes re-face protonation. The reaction tolerates various arylboronic acids and can be used in the gram-scale synthesis of (S)-phenylalanine hydrochloride, demonstrating the reaction scope and the synthetic feasibility of the process.
ASJC Scopus subject areas
指紋深入研究「Asymmetric Synthesis of Functionalized Phenylalanine Derivatives via Rh-Catalyzed Conjugate Addition and Enantioselective Protonation Cascade」主題。共同形成了獨特的指紋。
Jian, J. (Contributor), Zeng, H. (Contributor), Kuo, T. (Contributor), Wu, P. (Contributor) & Wu, H. (Contributor), Unknown Publisher, 2019