TY - JOUR
T1 - Asymmetric Organocatalytic Reactions of Activated Racemic Allenes
AU - Jamwal, Paru
AU - Vaid, Himani
AU - Ananda Rao, Gunda
AU - Gurubrahamam, Ramani
AU - Chen, Kwunmin
N1 - Funding Information:
PJ and HV thankful to the UGC and IIT Jammu for fellowships, respectively. KC and RG thankful to the MOST and DST‐SERB (SRG/2021/001539)for financial support, respectively.
Funding Information:
PJ and HV thankful to the UGC and IIT Jammu for fellowships, respectively. KC and RG thankful to the MOST and DST-SERB (SRG/2021/001539)for financial support, respectively.
Publisher Copyright:
© 2022 Wiley-VCH GmbH.
PY - 2022/12
Y1 - 2022/12
N2 - Asymmetric organocatalytic reactions of various electron-deficient racemic allenes with a wide variety of nucleophiles and electrophiles were reviewed. The literature on enantioselective functionalization of allenes that employs chiral phosphine, amine, phase transfer, bifunctional, and Brønsted acid catalysis is presented along with the mechanisms. In addition, the review emphasizes methods of obtaining enantioenriched allenes from racemic allenes via organocatalytic (dynamic) kinetic resolution techniques. The synthetic utility of the developed methodologies toward the target-orientated biologically active molecules is narrated along with the examples.
AB - Asymmetric organocatalytic reactions of various electron-deficient racemic allenes with a wide variety of nucleophiles and electrophiles were reviewed. The literature on enantioselective functionalization of allenes that employs chiral phosphine, amine, phase transfer, bifunctional, and Brønsted acid catalysis is presented along with the mechanisms. In addition, the review emphasizes methods of obtaining enantioenriched allenes from racemic allenes via organocatalytic (dynamic) kinetic resolution techniques. The synthetic utility of the developed methodologies toward the target-orientated biologically active molecules is narrated along with the examples.
KW - Allenes
KW - Annulations
KW - Asymmetric Organocatalysis
KW - Deracemization
KW - Kinetic Resolution
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U2 - 10.1002/ajoc.202200622
DO - 10.1002/ajoc.202200622
M3 - Review article
AN - SCOPUS:85142908973
SN - 2193-5807
VL - 11
JO - Asian Journal of Organic Chemistry
JF - Asian Journal of Organic Chemistry
IS - 12
M1 - e202200622
ER -