Association between phthalate exposure and the risk of depressive symptoms in the adult population of the United States

Chien Ju Wang, Hui Wen Yang, Ming Chieh Li*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

1 引文 斯高帕斯(Scopus)

摘要

Previous research has suggested an association between phthalate exposure and depressive symptoms, but the evidence is limited. Our study aimed to examine the association between phthalate exposure and the risk of depressive symptoms in the US adult population. We used data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018 to analyze the association between urinary phthalates and depressive symptoms. We included 11 urinary phthalate metabolites in our analysis and used the 9-item Patient Health Questionnaire (PHQ-9) to assess the presence of depression among study participants. Participants were divided into quartiles for each urinary phthalate metabolite, and we evaluated the association using a generalized linear mixed model with a logit link and binary distribution. A total of 7340 participants were included in the final analysis. After controlling for potential confounders, we found a positive association between the molar sum of di (2-ethylhexyl) phthalate (DEHP) metabolites and depressive symptoms, with an odds ratio of 1.30 (95% CI = 1.02–1.66) for the highest compared to the lowest quartile. In addition, we found positive associations of mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono (2-ethyl-5-carboxypentyl) phthalate (MECPP) with depressive symptoms, with odds ratios of 1.43 (95% CI = 1.12–1.81, p for trend = 0.02) and 1.44 (95% CI = 1.13–1.84, p for trend = 0.02), respectively, when comparing the highest quartile to the lowest quartile. In conclusion, this study is the first to identify a positive association between DEHP metabolites and the risk of depressive symptoms in the general adult population in the United States.

原文英語
文章編號139031
期刊Chemosphere
334
DOIs
出版狀態已發佈 - 2023 9月

ASJC Scopus subject areas

  • 環境工程
  • 環境化學
  • 一般化學
  • 污染
  • 公共衛生、環境和職業健康
  • 健康、毒理學和誘變

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