Association between PARK16 and Parkinson's disease in the Han Chinese population: A meta-analysis

Kuo Hsuan Chang, Chiung Mei Chen, Yi Chun Chen, Rong Kuo Lyu, Hong Shiu Chang, Long Sun Ro, Guey Jen Lee-Chen, Yih Ru Wu

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

摘要

PARK16 was reported to alter the risk for Parkinson's disease (PD) in the Japanese population. However, its role in Han Chinese PD patients has not been well established. Herein, we investigated the effect of 4 single-nucleotide polymorphisms (SNPs) within the PARK16 locus, including rs823128, rs947211, rs823156, and rs11240572, on the risk of PD by genotyping 497 Taiwanese patients with PD and 500 age-matched control subjects. The results were then meta-analyzed with available genetic association studies in the same population. The meta-analysis showed that PD patients demonstrated a lower frequency of the rs823128 G allele (11.93%) than control subjects (14.04%; odds ratio [OR] 0.83, 95% confidence interval [CI] 0.72-0.96, p= 0.010). The frequency of the rs947211 A allele (40.35%) in PD patients was lower than in control subjects (43.01%; OR 0.90, 95% CI 0.80-0.99, p= 0.047). The rs823156 G allele was less frequently seen in PD patients (17.32%) than in control subjects (21.35%; OR 0.77, 95% CI 0.69-0.86, p<0.001). A lower frequency of the rs11240572 A allele was found in PD patients (14.01%) than in control subjects (17.66%; OR 0.76, 95% CI 0.66-0.88, p < 0.001). Our results indicate a robust protective effect of PARK16 in Han Chinese PD patients. Functional approaches are needed to elucidate the effects of these SNPs on the regulation of gene expression.

原文英語
頁(從 - 到)2442.e5-2442.e9
期刊Neurobiology of Aging
34
發行號10
DOIs
出版狀態已發佈 - 2013 十月

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

指紋 深入研究「Association between PARK16 and Parkinson's disease in the Han Chinese population: A meta-analysis」主題。共同形成了獨特的指紋。

  • 引用此

    Chang, K. H., Chen, C. M., Chen, Y. C., Lyu, R. K., Chang, H. S., Ro, L. S., Lee-Chen, G. J., & Wu, Y. R. (2013). Association between PARK16 and Parkinson's disease in the Han Chinese population: A meta-analysis. Neurobiology of Aging, 34(10), 2442.e5-2442.e9. https://doi.org/10.1016/j.neurobiolaging.2013.04.028