Application of Rh(I)/Bicyclo[2.2.1]heptadiene Catalysts to the Enantioselective Synthesis of Chiral Amines

Yu Yi Cheng, Wei Sian Li, Hsyueh Liang Wu*

*此作品的通信作者

研究成果: 雜誌貢獻回顧評介論文同行評審

摘要

The development of efficient synthetic methods for accessing enantioenriched α-chiral amines is of great importance in the disciplines of medicinal and synthetic organic chemistry. Enantioselective Rh-catalyzed 1,2-addition reactions to activated imine derivatives are regarded as useful protocols for forming α-chiral amines. This personal account outlines our efforts to develop chiral bicyclo[2.2.1]heptadiene ligands for Rh-catalyzed asymmetric additions of various organoboron reagents to a wide range of imine derivatives. Transformations of the thus-obtained adducts into known natural products or molecules of pharmaceutical importance serve to confirm their synthetic usefulness.

原文英語
頁(從 - 到)3954-3963
頁數10
期刊Chemical Record
21
發行號12
DOIs
出版狀態已發佈 - 2021 12月

ASJC Scopus subject areas

  • 化學 (全部)
  • 生物化學
  • 化學工程 (全部)
  • 材料化學

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