Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia

H. K. Wang, H. C. Fung, W. C. Hsu, Y. R. Wu, J. C. Lin, L. S. Ro, K. H. Chang, F. J. Hwu, Y. Hsu, S. Y. Huang, G. J. Lee-Chen*, C. M. Chen

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

39 引文 斯高帕斯(Scopus)

摘要

Lipoproteins and vascular factors may play roles in the development of Alzheimer's disease (AD) and/or vascular dementia (VaD). In this study, odd ratios (ORs) and 95% confidence intervals (CIs) for apolipoprotein E (APOE), angiotensin-converting enzyme (ACE), and kallikrein (KLK1) polymorphisms were computed to test their association with the disease by a case-control study. The risk of AD was significantly increased for individuals with APOE ε4 allele (OR = 3.73, 95% CI = 2.38-5.98). The risk of AD was also significant for people with ACE DD genotype, D allele, or T-D haplotype [OR (95% CI) = 4.29 (1.96-10.23), 1.90 (1.35-2.70), or 2.91 (1.71-5.10), respectively]. The above association between ACE-VaD was also strong (p = 0.0012, 0.0050, 0.0007, respectively). Reporter constructs containing the -240 A or T allele displayed similar transcriptional activity in both HEK-293 and IMR-32 cells. Thus, another putative pathogenic marker that is linked with the Alu D allele might affect the risk of AD and VaD in Taiwan.

原文英語
頁(從 - 到)1499-1509
頁數11
期刊Journal of Neural Transmission
113
發行號10
DOIs
出版狀態已發佈 - 2006 10月

ASJC Scopus subject areas

  • 神經內科
  • 神經病學(臨床)
  • 精神病學和心理健康
  • 生物精神病學

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