Anti-CEA-functionalized superparamagnetic iron oxide nanoparticles for examining colorectal tumors in vivo

Kai Wen Huang, Jen Jie Chieh, In Tsang Lin, Herng Er Horng, Hong Chang Yang, Chin Yih Hong

    研究成果: 雜誌貢獻文章同行評審

    9 引文 斯高帕斯(Scopus)

    摘要

    Although the biomarker carcinoembryonic antigen (CEA) is expressed in colorectal tumors, the utility of an anti-CEA-functionalized image medium is powerful for in vivo positioning of colorectal tumors. With a risk of superparamagnetic iron oxide nanoparticles (SPIONPs) that is lower for animals than other material carriers, anti-CEA-functionalized SPIONPs were synthesized in this study for labeling colorectal tumors by conducting different preoperatively and intraoperatively in vivo examinations. In magnetic resonance imaging (MRI), the image variation of colorectal tumors reached the maximum at approximately 24 h. However, because MRI requires a nonmetal environment, it was limited to preoperative imaging. With the potentiality of in vivo screening and intraoperative positioning during surgery, the scanning superconducting-quantum-interference-device biosusceptometry (SSB) was adopted, showing the favorable agreement of time-varied intensity with MRI. Furthermore, biological methodologies of different tissue staining methods and inductively coupled plasma (ICP) yielded consistent results, proving that the obtained in vivo results occurred because of targeted anti-CEA SPIONPs. This indicates that developed anti-CEA SPIONPs owe the utilities as an image medium of these in vivo methodologies.

    原文英語
    文章編號413
    頁(從 - 到)1-8
    頁數8
    期刊Nanoscale Research Letters
    8
    發行號1
    DOIs
    出版狀態已發佈 - 2013 一月 1

    ASJC Scopus subject areas

    • Materials Science(all)
    • Condensed Matter Physics

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