Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities

Richard S. Metcalfe*, Rachael Kemp, Shane M. Heffernan, Rachel Churm, Yung Chih Chen, José S. Ruffino, Gillian E. Conway, Giusy Tornillo, Samuel T. Orange


研究成果: 雜誌貢獻回顧評介論文同行評審

6 引文 斯高帕斯(Scopus)


Regular physical activity reduces the risk of several site-specific cancers in humans and suppresses tumour growth in animal models. The mechanisms through which exercise reduces tumour growth remain incompletely understood, but an intriguing and accumulating body of evidence suggests that the incubation of cancer cells with post-exercise serum can have powerful effects on key hallmarks of cancer cell behaviour in vitro. This suggests that exercise can impact tumour biology through direct changes in circulating proteins, RNA molecules and metabolites. Here, we provide a comprehensive narrative overview of what is known about the effects of exercise-conditioned sera on in vitro cancer cell behaviour. In doing so, we consider the key limitations of the current body of literature, both from the perspective of exercise physiology and cancer biology, and we discuss the potential in vivo physiological relevance of these findings. We propose key opportunities for future research in an area that has the potential to identify key anti-oncogenic protein targets and optimise physical activity recommendations for cancer prevention, treatment and survivorship.

頁(從 - 到)2107-2124
期刊European Journal of Applied Physiology
出版狀態已發佈 - 2021 8月

ASJC Scopus subject areas

  • 骨科和運動醫學
  • 公共衛生、環境和職業健康
  • 生理學(醫學)


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