Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

E. K. Tan; C. S. Lu; R. Peng; Y. Y. Teo; Y. H. Wu-Chou; R. S. Chen; Y. H. Weng; C. M. Chen; H. C. Fung; L. C. Tan; Z. J. Zhang; X. K. An; G. J. Lee-Chen; M. C. Lee; S. Fook-Chong; J. M. Burgunder; R. M. Wu; Y. R. Wu

doi:10.1016/j.neurobiolaging.2008.11.008

Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

E. K. Tan, C. S. Lu, R. Peng, Y. Y. Teo, Y. H. Wu-Chou, R. S. Chen, Y. H. Weng, C. M. Chen, H. C. Fung, L. C. Tan, Z. J. Zhang, X. K. An, G. J. Lee-Chen, M. C. Lee, S. Fook-Chong, J. M. Burgunder, R. M. Wu, Y. R. Wu^*

^*此作品的通信作者

生命科學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

13 引文斯高帕斯（Scopus）

摘要

The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.

原文	英語
頁（從 - 到）	2194-2196
頁數	3
期刊	Neurobiology of Aging
卷	31
發行號	12
DOIs	https://doi.org/10.1016/j.neurobiolaging.2008.11.008
出版狀態	已發佈 - 2010 12月

ASJC Scopus subject areas

神經科學 (全部)
老化
發展生物學
神經病學（臨床）
老年病學和老年學

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10.1016/j.neurobiolaging.2008.11.008

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Tan, E. K., Lu, C. S., Peng, R., Teo, Y. Y., Wu-Chou, Y. H., Chen, R. S., Weng, Y. H., Chen, C. M., Fung, H. C., Tan, L. C., Zhang, Z. J., An, X. K., Lee-Chen, G. J., Lee, M. C., Fook-Chong, S., Burgunder, J. M., Wu, R. M., & Wu, Y. R. (2010). Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese. Neurobiology of Aging, 31(12), 2194-2196. https://doi.org/10.1016/j.neurobiolaging.2008.11.008

Tan, EK, Lu, CS, Peng, R, Teo, YY, Wu-Chou, YH, Chen, RS, Weng, YH, Chen, CM, Fung, HC, Tan, LC, Zhang, ZJ, An, XK, Lee-Chen, GJ, Lee, MC, Fook-Chong, S, Burgunder, JM, Wu, RM & Wu, YR 2010, 'Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese', Neurobiology of Aging, 卷 31, 編號 12, 頁 2194-2196. https://doi.org/10.1016/j.neurobiolaging.2008.11.008

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title = "Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese",

abstract = "The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.",

keywords = "Parkinson's disease, Polymorphism, UCHL1",

author = "Tan, {E. K.} and Lu, {C. S.} and R. Peng and Teo, {Y. Y.} and Wu-Chou, {Y. H.} and Chen, {R. S.} and Weng, {Y. H.} and Chen, {C. M.} and Fung, {H. C.} and Tan, {L. C.} and Zhang, {Z. J.} and An, {X. K.} and Lee-Chen, {G. J.} and Lee, {M. C.} and S. Fook-Chong and Burgunder, {J. M.} and Wu, {R. M.} and Wu, {Y. R.}",

note = "Funding Information: We thank the support from the National Medical Research Council, Biomedical Research Council, Duke-NUS Graduate Medical School, Singapore Millennium Foundation, SingHealth, West China Hospital, Sichuan University, Chengdu, China, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taipei, Taiwan, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. ",

year = "2010",

month = dec,

doi = "10.1016/j.neurobiolaging.2008.11.008",

language = "English",

volume = "31",

pages = "2194--2196",

journal = "Neurobiology of Aging",

issn = "0197-4580",

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TY - JOUR

T1 - Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

AU - Tan, E. K.

AU - Lu, C. S.

AU - Peng, R.

AU - Teo, Y. Y.

AU - Wu-Chou, Y. H.

AU - Chen, R. S.

AU - Weng, Y. H.

AU - Chen, C. M.

AU - Fung, H. C.

AU - Tan, L. C.

AU - Zhang, Z. J.

AU - An, X. K.

AU - Lee-Chen, G. J.

AU - Lee, M. C.

AU - Fook-Chong, S.

AU - Burgunder, J. M.

AU - Wu, R. M.

AU - Wu, Y. R.

N1 - Funding Information: We thank the support from the National Medical Research Council, Biomedical Research Council, Duke-NUS Graduate Medical School, Singapore Millennium Foundation, SingHealth, West China Hospital, Sichuan University, Chengdu, China, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taipei, Taiwan, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

PY - 2010/12

Y1 - 2010/12

N2 - The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.

AB - The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.

KW - Parkinson's disease

KW - Polymorphism

KW - UCHL1

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SN - 0197-4580

VL - 31

SP - 2194

EP - 2196

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 12

ER -

Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

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