Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

Owen A. Ross; Yih Ru Wu; Mei Ching Lee; Manabu Funayama; Meng Ling Chen; Alexandra I. Soto; Ignacio F. Mata; Guey Jen Lee-Chen; Mei Chen Chiung; Michelle Tang; Yi Zhao; Nobutaka Hattori; Matthew J. Farrer; Eng King Tan; Ruey Meei Wu

doi:10.1002/ana.21405

Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

Owen A. Ross, Yih Ru Wu^*, Mei Ching Lee, Manabu Funayama, Meng Ling Chen, Alexandra I. Soto, Ignacio F. Mata, Guey Jen Lee-Chen, Mei Chen Chiung, Michelle Tang, Yi Zhao, Nobutaka Hattori, Matthew J. Farrer, Eng King Tan, Ruey Meei Wu

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生命科學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

169 引文斯高帕斯（Scopus）

摘要

Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease.

原文	英語
頁（從 - 到）	88-92
頁數	5
期刊	Annals of Neurology
卷	64
發行號	1
DOIs	https://doi.org/10.1002/ana.21405
出版狀態	已發佈 - 2008 7月

ASJC Scopus subject areas

神經內科
神經病學（臨床）

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10.1002/ana.21405

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title = "Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease",

abstract = "Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease.",

author = "Ross, {Owen A.} and Wu, {Yih Ru} and Lee, {Mei Ching} and Manabu Funayama and Chen, {Meng Ling} and Soto, {Alexandra I.} and Mata, {Ignacio F.} and Lee-Chen, {Guey Jen} and Chiung, {Mei Chen} and Michelle Tang and Yi Zhao and Nobutaka Hattori and Farrer, {Matthew J.} and Tan, {Eng King} and Wu, {Ruey Meei}",

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AU - Ross, Owen A.

AU - Wu, Yih Ru

AU - Lee, Mei Ching

AU - Funayama, Manabu

AU - Chen, Meng Ling

AU - Soto, Alexandra I.

AU - Mata, Ignacio F.

AU - Lee-Chen, Guey Jen

AU - Chiung, Mei Chen

AU - Tang, Michelle

AU - Zhao, Yi

AU - Hattori, Nobutaka

AU - Farrer, Matthew J.

AU - Tan, Eng King

AU - Wu, Ruey Meei

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N2 - Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease.

AB - Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease.

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Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

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