Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

Owen A. Ross, Yih Ru Wu*, Mei Ching Lee, Manabu Funayama, Meng Ling Chen, Alexandra I. Soto, Ignacio F. Mata, Guey Jen Lee-Chen, Mei Chen Chiung, Michelle Tang, Yi Zhao, Nobutaka Hattori, Matthew J. Farrer, Eng King Tan, Ruey Meei Wu

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

151 引文 斯高帕斯(Scopus)

摘要

Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease.

原文英語
頁(從 - 到)88-92
頁數5
期刊Annals of Neurology
64
發行號1
DOIs
出版狀態已發佈 - 2008 七月

ASJC Scopus subject areas

  • 神經內科
  • 神經病學(臨床)

指紋

深入研究「Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease」主題。共同形成了獨特的指紋。

引用此