An ultrasonic technique for the measurement of the elastic moduli of human cornea

Hsichun Wang, Paul L. Prendiville, Peter J. McDonnell, Wenji V. Chang*


研究成果: 雜誌貢獻期刊論文同行評審

77 引文 斯高帕斯(Scopus)


In the hopes of reducing the unpredictability associated with refractive surgical procedures and ultimately improving surgical techniques, many investigators have attempted to determine the elastic moduli of the cornea. Techniques such as stress-strain tests of corneal strips and the measurement of mercury drop displacement in a whole eye under increasing pressure have resulted in a range of values for Young's modulus from 105 to 107 N m-2. Both of these methods are limited because these mechanical tests cannot be performed in the physiological state and because of the large amount of force applied during testing. We used an ultrasonic technique to determine the elastic moduli of the human cornea. Two groups of six corneas prepared under different conditions (in saline and in dextran) were examined separately and the shear waves were generated and detected in these 12 human eye bank eyes. All the waveforms were digitized and saved in files of binary format. Fast Fourier transformation (FFT) was applied to calculate the speed and attenuation of the shear wave. Using the resulting wave speeds and attenuation coefficients, the Young's moduli of the corneal samples were calculated as (5.3 ± 1.1) × 106 N m-2 and (2.0 ± 1.0) × 107 N m-2 for cornea samples prepared in saline and in dextran at 2.25 MHz, respectively.

頁(從 - 到)1633-1636
期刊Journal of Biomechanics
出版狀態已發佈 - 1996 12月

ASJC Scopus subject areas

  • 生物物理學
  • 復健
  • 生物醫學工程
  • 骨科和運動醫學


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