An experimental model to evaluate the in vivo response of rat seminal vesicle to electrical stimulation

Ju Ton Hsieh, Chiang Ting Chien, Shih Ping Liu, Chau Fong Chen, Ming Kuen Lai

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

This investigation demonstrated a good model to record the pressure change of rat seminal vesicle (SV) in response to electrical stimulation (ES) of lesser splanchnic nerve (LSN) in vivo. LSN was easily identified and isolated grossly. Antegrade catheterization via the SV tail to the main lumen was performed similar to the technique of i.v. catheterization, and the pressure recording was quite satisfactory. The vesicle response to ES was frequency-dependent and reproducible. Under the conditions of 10 V and 1 ms, the maximal vesicle pressure was 81.7 ± 2.8 mmHg with 80 Hz of ES. The inhibitory response of SV to ES by clomipramine was concentration-dependent. Clomipramine (3 mg/kg) could inhibit 53% of control responses (n = 7). This experimental model is relevant to neurophysiologic and neuropharmacologic studies of SV.

原文英語
頁(從 - 到)215-217
頁數3
期刊Neuroscience Letters
204
發行號3
DOIs
出版狀態已發佈 - 1996 二月 9

ASJC Scopus subject areas

  • Neuroscience(all)

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