An estimate of the incidence of dementia in idiopathic parkinson’s disease

R. Mayeux, J. Chen, E. Mirabello, K. Marder, K. Bell, G. Dooneief, L. Cote, Y. Stern

研究成果: 雜誌貢獻文章

148 引文 (Scopus)

摘要

The proportion of patients with idiopathic Parkinson’s disease (PD) who are considered demented ranges from 10% to 15%. Because dementia may affect survival in PD, the incidence rate of dementia, rather than proportion, would be a more accurate measure of disease frequency. We previously estimated the proportion of patients with PD and dementia to be 10.9% from the records of a cohort with the idiopathic form of PD in a major medical center. We reviewed the clinical records of this cohort after 4 years and 9 months to estimate the incidence rate of dementia. We identified 65 new cases of dementia from the 249 patient-records available. Using the number of person-years of follow-up for each case as the denominator, we estimated the overall incidence rate to be 69 per 1,000 person-years of observation. The mean age of this cohort was 71.4 years. The cumulative incidence of dementia increased with age. By 85 years of age, over 65% of the surviving members of the cohort were demented. The age-specific incidence rates for dementia in this cohort of PD were significantly greater than for a similarly aged cohort of healthy elderly people. The age-specific standard morbidity ratios indicated that, compared with people of similar ages, patients with PD have the highest increase in risk for dementia between ages 65 and 75.

原文英語
頁(從 - 到)1513-1517
頁數5
期刊Neurology
40
發行號10
出版狀態已發佈 - 1990
對外發佈Yes

指紋

Parkinson Disease
Dementia
Incidence
Parkinson's Disease
Cohort
Observation
Morbidity
Survival
Proportion

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

引用此文

Mayeux, R., Chen, J., Mirabello, E., Marder, K., Bell, K., Dooneief, G., ... Stern, Y. (1990). An estimate of the incidence of dementia in idiopathic parkinson’s disease. Neurology, 40(10), 1513-1517.

An estimate of the incidence of dementia in idiopathic parkinson’s disease. / Mayeux, R.; Chen, J.; Mirabello, E.; Marder, K.; Bell, K.; Dooneief, G.; Cote, L.; Stern, Y.

於: Neurology, 卷 40, 編號 10, 1990, p. 1513-1517.

研究成果: 雜誌貢獻文章

Mayeux, R, Chen, J, Mirabello, E, Marder, K, Bell, K, Dooneief, G, Cote, L & Stern, Y 1990, 'An estimate of the incidence of dementia in idiopathic parkinson’s disease', Neurology, 卷 40, 編號 10, 頁 1513-1517.
Mayeux R, Chen J, Mirabello E, Marder K, Bell K, Dooneief G 等. An estimate of the incidence of dementia in idiopathic parkinson’s disease. Neurology. 1990;40(10):1513-1517.
Mayeux, R. ; Chen, J. ; Mirabello, E. ; Marder, K. ; Bell, K. ; Dooneief, G. ; Cote, L. ; Stern, Y. / An estimate of the incidence of dementia in idiopathic parkinson’s disease. 於: Neurology. 1990 ; 卷 40, 編號 10. 頁 1513-1517.
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