An efficient of Grignard-type procedure for the preparation of gem-diallylated compound

Kao Hsien Shen; Chun Wei Kuo; Ching Fa Yao

doi:10.1016/j.tetlet.2007.07.008

An efficient of Grignard-type procedure for the preparation of gem-diallylated compound

Kao Hsien Shen
, Chun Wei Kuo
, Ching Fa Yao^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

12 引文斯高帕斯（Scopus）

摘要

An efficient and a new procedure for the conversion of various carboxylic acid derivatives into the corresponding gem-diallylated compound under mild reaction condition has been developed. The triallylaluminum mediated Grignard-type addition of carboxylic acid derivative was utilized as a key operation to affect the transformation. The procedure is operationally simple, giving good to excellent product yields for a broad range of substrates. The chemoselectivity and regioselectivity of triallylaluminum were also demonstrated.

原文	英語
頁（從 - 到）	6348-6351
頁數	4
期刊	Tetrahedron Letters
卷	48
發行號	36
DOIs	https://doi.org/10.1016/j.tetlet.2007.07.008
出版狀態	已發佈 - 2007 9月 3

ASJC Scopus subject areas

生物化學
藥物發現
有機化學

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10.1016/j.tetlet.2007.07.008

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title = "An efficient of Grignard-type procedure for the preparation of gem-diallylated compound",

abstract = "An efficient and a new procedure for the conversion of various carboxylic acid derivatives into the corresponding gem-diallylated compound under mild reaction condition has been developed. The triallylaluminum mediated Grignard-type addition of carboxylic acid derivative was utilized as a key operation to affect the transformation. The procedure is operationally simple, giving good to excellent product yields for a broad range of substrates. The chemoselectivity and regioselectivity of triallylaluminum were also demonstrated.",

author = "Shen, \{Kao Hsien\} and Kuo, \{Chun Wei\} and Yao, \{Ching Fa\}",

note = "Funding Information: Financial support provided by the National Science Council of the Republic of China and National Taiwan Normal University (96TOP001) is gratefully acknowledged. We also thank Professor Dr. Milton. S. Feather, for his helpful discussions during the preparation of this manuscript. ",

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T1 - An efficient of Grignard-type procedure for the preparation of gem-diallylated compound

AU - Shen, Kao Hsien

AU - Kuo, Chun Wei

AU - Yao, Ching Fa

N1 - Funding Information: Financial support provided by the National Science Council of the Republic of China and National Taiwan Normal University (96TOP001) is gratefully acknowledged. We also thank Professor Dr. Milton. S. Feather, for his helpful discussions during the preparation of this manuscript.

PY - 2007/9/3

Y1 - 2007/9/3

N2 - An efficient and a new procedure for the conversion of various carboxylic acid derivatives into the corresponding gem-diallylated compound under mild reaction condition has been developed. The triallylaluminum mediated Grignard-type addition of carboxylic acid derivative was utilized as a key operation to affect the transformation. The procedure is operationally simple, giving good to excellent product yields for a broad range of substrates. The chemoselectivity and regioselectivity of triallylaluminum were also demonstrated.

AB - An efficient and a new procedure for the conversion of various carboxylic acid derivatives into the corresponding gem-diallylated compound under mild reaction condition has been developed. The triallylaluminum mediated Grignard-type addition of carboxylic acid derivative was utilized as a key operation to affect the transformation. The procedure is operationally simple, giving good to excellent product yields for a broad range of substrates. The chemoselectivity and regioselectivity of triallylaluminum were also demonstrated.

UR - https://www.scopus.com/pages/publications/34547673297

UR - https://www.scopus.com/pages/publications/34547673297#tab=citedBy

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DO - 10.1016/j.tetlet.2007.07.008

M3 - Article

AN - SCOPUS:34547673297

SN - 0040-4039

VL - 48

SP - 6348

EP - 6351

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 36

ER -

An efficient of Grignard-type procedure for the preparation of gem-diallylated compound

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