An efficient Morita-Baylis-Hillman reaction for the synthesis of multifunctional 2-hydroxy-3-nitrobut-3-enoate derivatives

Hsuan Hao Kuan, Raju Jannapu Reddy, Kwunmin Chen

研究成果: 雜誌貢獻文章

30 引文 斯高帕斯(Scopus)

摘要

An efficient thiourea promoted MBH reaction of various conjugated nitroalkenes with ethyl glyoxylate was developed. The desired multifunctional products, 2-hydroxy-3-nitro-4-aryl/alkylbut-3-enoate derivatives were obtained in good to high chemical yields (56-92%) with DMAP (20 mol %) under solvent-free conditions or imidazole (100 mol %) in the presence of water.

原文英語
頁(從 - 到)9875-9879
頁數5
期刊Tetrahedron
66
發行號52
DOIs
出版狀態已發佈 - 2010 十二月 24

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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