An efficient diastereoselective glyoxylate-ene reaction using N-glyoxyloyl camphorpyrazolidinone as an enophile

Jia Fu Pan, Uppala Venkatesham, Kwunmin Chen

研究成果: 雜誌貢獻期刊論文同行評審

8 引文 斯高帕斯(Scopus)

摘要

The diastereoselective glyoxylate-ene reaction of N-glyoxyloyl camphorpyrazolidinone (1) with various alkenes 2a-g in the presence of Lewis acid is described. The corresponding α-hydroxyl carbonyls were generally obtained in moderate to high chemical yields (64-87%) and with high levels of diastereoselectivities (up to 94% de). The predominance of products with the S absolute configuration at the newly formed stereogenic center was established by single crystal X-ray analysis and the importance of stereochemical induction is discussed.

原文英語
頁(從 - 到)9345-9347
頁數3
期刊Tetrahedron Letters
45
發行號51
DOIs
出版狀態已發佈 - 2004 十二月 13

ASJC Scopus subject areas

  • 生物化學
  • 藥物發現
  • 有機化學

指紋

深入研究「An efficient diastereoselective glyoxylate-ene reaction using N-glyoxyloyl camphorpyrazolidinone as an enophile」主題。共同形成了獨特的指紋。

引用此