Access to β 2 -Amino Acids via Enantioselective 1,4-Arylation of β-Nitroacrylates Catalyzed by Chiral Rhodium Catalysts

Jia Hong Jian, Chih Lung Hsu, Jin Fong Syu, Ting Shen Kuo, Ming Kang Tsai, Ping Yu Wu, Hsyueh Liang Wu

研究成果: 雜誌貢獻期刊論文同行評審

14 引文 斯高帕斯(Scopus)

摘要

The highly enantioselective conjugate addition of a variety of arylboronic acids to β-nitroacrylates is reported to provide optically active α-aryl β-nitropropionates in up to 70% yields and >99.5% ee's, which are useful building blocks for preparing chiral β 2 -amino acids. The applicability of this transformation is demonstrated by converting 3aa into the β 2 -amino acid 5 and transforming 3ap to β-amino ester 7 via reduction and reductive N-alkylation. The latter compound is a precursor for preparing ent-ipatasertib.

原文英語
頁(從 - 到)12184-12191
頁數8
期刊Journal of Organic Chemistry
83
發行號19
DOIs
出版狀態已發佈 - 2018 十月 5

ASJC Scopus subject areas

  • 有機化學

指紋

深入研究「Access to β <sup>2</sup> -Amino Acids via Enantioselective 1,4-Arylation of β-Nitroacrylates Catalyzed by Chiral Rhodium Catalysts」主題。共同形成了獨特的指紋。

引用此