A vinylogous Michael addition-triggered quadruple cascade reaction for the enantioselective generation of multiple quaternary stereocenters

Shu Mei Yang, Praneeth Karanam, Min Wang, Yeong Jiunn Jang, Yu Sheng Yeh, Ping Yao Tseng, Madhusudhan Reddy Ganapuram, Yan Cheng Liou, Wenwei Lin

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

An efficient organocatalytic quadruple cascade reaction resulting in spiroxindole scaffolds bearing five quaternary stereocenters is reported. The complex cascade reaction is triggered by the scarcely explored vinylogous Michael addition of 3-alkylidene oxindoles to fully substituted enones and demonstrates the usefulness of the latter as efficient Michael acceptors in generating complex caged products in 26-92% yields, 14-98% ee and up to >25:1 d.r. values.

原文英語
頁(從 - 到)1398-1401
頁數4
期刊Chemical Communications
55
發行號10
DOIs
出版狀態已發佈 - 2019 一月 1

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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