摘要
The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1–1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7–50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1–3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.
原文 | 英語 |
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文章編號 | 311 |
期刊 | Journal of Nanobiotechnology |
卷 | 20 |
發行號 | 1 |
DOIs | |
出版狀態 | 已發佈 - 2022 12月 |
ASJC Scopus subject areas
- 生物工程
- 醫藥(雜項)
- 分子醫學
- 生物醫學工程
- 應用微生物與生物技術
- 藥學科學
指紋
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A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges
Yang, L.-X. (Creator), Liu, Y.-C. (Creator), Cho, C.-H. (Creator), Chen, Y.-R. (Creator), Yang, C.-S. (Creator), Lu, Y.-L. (Creator), Zhang, Z. (Creator), Tsai, Y.-T. (Creator), Chin, Y.-C. (Creator), Yu, J. (Creator), Pan, H.-M. (Creator), Jiang, W.-R. (Creator), Chia, Z.-C. (Creator), Huang, W.-S. (Creator), Chiu, Y.-L. (Creator), Sun, C.-K. (Creator), Huang, Y.-T. (Creator), Chen, L.-M. (Creator), Wong, K.-T. (Creator), Huang, H.-M. (Creator), Chen, C.-H. (Creator), Chang, Y. J. (Creator), Huang, C.-C. (Creator) & Liu, T.-M. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6083480, https://springernature.figshare.com/collections/A_universal_strategy_for_the_fabrication_of_single-photon_and_multiphoton_NIR_nanoparticles_by_loading_organic_dyes_into_water-soluble_polymer_nanosponges/6083480
資料集: Dataset
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A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges
Yang, L.-X. (Creator), Liu, Y.-C. (Creator), Cho, C.-H. (Creator), Chen, Y.-R. (Creator), Yang, C.-S. (Creator), Lu, Y.-L. (Creator), Zhang, Z. (Creator), Tsai, Y.-T. (Creator), Chin, Y.-C. (Creator), Yu, J. (Creator), Pan, H.-M. (Creator), Jiang, W.-R. (Creator), Chia, Z.-C. (Creator), Huang, W.-S. (Creator), Chiu, Y.-L. (Creator), Sun, C.-K. (Creator), Huang, Y.-T. (Creator), Chen, L.-M. (Creator), Wong, K.-T. (Creator), Huang, H.-M. (Creator), Chen, C.-H. (Creator), Chang, Y. J. (Creator), Huang, C.-C. (Creator) & Liu, T.-M. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6083480.v1, https://springernature.figshare.com/collections/A_universal_strategy_for_the_fabrication_of_single-photon_and_multiphoton_NIR_nanoparticles_by_loading_organic_dyes_into_water-soluble_polymer_nanosponges/6083480/1
資料集: Dataset