@article{812fa9c5b66b4d26be913c67cae6f17d,
title = "A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges",
abstract = "The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1–1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7–50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1–3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.",
keywords = "Fluorescence imaging, Multiphoton microscopy, Near-infrared red, Optoelectronic material, Photodynamic therapy, Polymer, Theranostic",
author = "Yang, {Li Xing} and Liu, {Yu Cheng} and Cho, {Chang Hui} and Chen, {Yi Rou} and Yang, {Chan Shan} and Lu, {Yin Lin} and Zhiming Zhang and Tsai, {Yi Tseng} and Chin, {Yu Cheng} and Jiashing Yu and Pan, {Hsiu Min} and Jiang, {Wei Rou} and Chia, {Zi Chun} and Huang, {Wei Shiang} and Chiu, {Yu Lin} and Sun, {Chun Kai} and Huang, {Yu Ting} and Chen, {Li Ming} and Wong, {Ken Tsung} and Huang, {Han Min} and Chen, {Chih Hsin} and Chang, {Yuan Jay} and Huang, {Chih Chia} and Liu, {Tzu Ming}",
note = "Funding Information: This work was sponsored by the Faculty of Health Sciences, University of Macau, the internal funding of the University of Macau under MYRG2018-00070-FHS, the grants funded by The Science and Technology Development Fund, Macau SAR (File No. 122/2016/A3, 018/2017/A1, FDCT/0011/2019/AKP, 0120/2020/A3 and 0026/2021/A), the Ministry of Science and Technology, Taiwan (MOST 108-2113-M-006-012-MY3, MOST 109-2113-M-029-009, MOST 109-2327-B-009-001, MOST 109-2113-M-032-002, MOST 108-2314-B-039-007-MY3, MOST 107-2113-M-002-019-MY3, MOST 110-2731-M-006-001, MOST 110-2221-E-002-013, and MOST 110-2112-M-003-012-MY3), the Center of Applied Nanomedicine, National Cheng Kung University from the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. The authors gratefully acknowledge the use of EM000800 belonging to the Core Facility Center of National Cheng Kung University. Funding Information: This work was sponsored by the Faculty of Health Sciences, University of Macau, the internal funding of the University of Macau under MYRG2018-00070-FHS, the Grants funded by The Science and Technology Development Fund, Macau SAR (File no. 122/2016/A3, 018/2017/A1, FDCT/0011/2019/AKP, 0120/2020/A3 and 0026/2021/A), the Ministry of Science and Technology, Taiwan (MOST 108-2113-M-006-012-MY3, MOST 109-2113-M-029-009, MOST 109-2327-B-009-001, MOST 109-2113-M-032-002, MOST 108-2314-B-039-007-MY3, MOST 107-2113-M-002-019-MY3, MOST 110-2731-M-006-001, MOST 110-2221-E-002-013, and MOST 110-2112-M-003-012-MY3). Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1186/s12951-022-01515-5",
language = "English",
volume = "20",
journal = "Journal of Nanobiotechnology",
issn = "1477-3155",
publisher = "BioMed Central",
number = "1",
}
