A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges

Li Xing Yang; Yu Cheng Liu; Chang Hui Cho; Yi Rou Chen; Chan Shan Yang; Yin Lin Lu; Zhiming Zhang; Yi Tseng Tsai; Yu Cheng Chin; Jiashing Yu; Hsiu Min Pan; Wei Rou Jiang; Zi Chun Chia; Wei Shiang Huang; Yu Lin Chiu; Chun Kai Sun; Yu Ting Huang; Li Ming Chen; Ken Tsung Wong; Han Min Huang; Chih Hsin Chen; Yuan Jay Chang; Chih Chia Huang; Tzu Ming Liu

doi:10.1186/s12951-022-01515-5

A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges

Li Xing Yang, Yu Cheng Liu, Chang Hui Cho, Yi Rou Chen, Chan Shan Yang, Yin Lin Lu, Zhiming Zhang, Yi Tseng Tsai, Yu Cheng Chin, Jiashing Yu, Hsiu Min Pan, Wei Rou Jiang, Zi Chun Chia, Wei Shiang Huang, Yu Lin Chiu, Chun Kai Sun, Yu Ting Huang, Li Ming Chen, Ken Tsung Wong, Han Min HuangChih Hsin Chen^*, Yuan Jay Chang^*, Chih Chia Huang^*, Tzu Ming Liu^*

^*此作品的通信作者

光電工程研究所

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

2 引文斯高帕斯（Scopus）

摘要

The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1–1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7–50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1–3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.

原文	英語
文章編號	311
期刊	Journal of Nanobiotechnology
卷	20
發行號	1
DOIs	https://doi.org/10.1186/s12951-022-01515-5
出版狀態	已發佈 - 2022 12月

ASJC Scopus subject areas

生物工程
醫藥（雜項）
分子醫學
生物醫學工程
應用微生物與生物技術
藥學科學

UN SDG

此研究成果有助於以下永續發展目標

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10.1186/s12951-022-01515-5

其它文件與鏈接

A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges
Yang, L. (Creator), Liu, Y. (Creator), Cho, C. (Creator), Chen, Y. (Creator), Yang, C. (Creator), Lu, Y. (Creator), Zhang, Z. (Creator), Tsai, Y. (Creator), Chin, Y. (Creator), Yu, J. (Creator), Pan, H. (Creator), Jiang, W. (Creator), Chia, Z. (Creator), Huang, W. (Creator), Chiu, Y. (Creator), Sun, C. (Creator), Huang, Y. (Creator), Chen, L. (Creator), Wong, K. (Creator), Huang, H. (Creator), Chen, C. (Creator), Chang, Y. J. (Creator), Huang, C. (Creator), Liu, T. (Creator), Liu, Y. (Creator) & Huang, Y. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6083480.v1, https://springernature.figshare.com/collections/A_universal_strategy_for_the_fabrication_of_single-photon_and_multiphoton_NIR_nanoparticles_by_loading_organic_dyes_into_water-soluble_polymer_nanosponges/6083480/1
資料集: Dataset
A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges
Yang, L. (Creator), Liu, Y. (Creator), Cho, C. (Creator), Chen, Y. (Creator), Yang, C. (Creator), Lu, Y. (Creator), Zhang, Z. (Creator), Tsai, Y. (Creator), Chin, Y. (Creator), Yu, J. (Creator), Pan, H. (Creator), Jiang, W. (Creator), Chia, Z. (Creator), Huang, W. (Creator), Chiu, Y. (Creator), Sun, C. (Creator), Huang, Y. (Creator), Chen, L. (Creator), Wong, K. (Creator), Huang, H. (Creator), Chen, C. (Creator), Chang, Y. J. (Creator), Huang, C. (Creator) & Liu, T. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6083480, https://springernature.figshare.com/collections/A_universal_strategy_for_the_fabrication_of_single-photon_and_multiphoton_NIR_nanoparticles_by_loading_organic_dyes_into_water-soluble_polymer_nanosponges/6083480
資料集: Dataset

引用此

Yang, L. X., Liu, Y. C., Cho, C. H., Chen, Y. R., Yang, C. S., Lu, Y. L., Zhang, Z., Tsai, Y. T., Chin, Y. C., Yu, J., Pan, H. M., Jiang, W. R., Chia, Z. C., Huang, W. S., Chiu, Y. L., Sun, C. K., Huang, Y. T., Chen, L. M., Wong, K. T., ... Liu, T. M. (2022). A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges. Journal of Nanobiotechnology, 20(1), Article 311. https://doi.org/10.1186/s12951-022-01515-5

Yang, LX, Liu, YC, Cho, CH, Chen, YR, Yang, CS, Lu, YL, Zhang, Z, Tsai, YT, Chin, YC, Yu, J, Pan, HM, Jiang, WR, Chia, ZC, Huang, WS, Chiu, YL, Sun, CK, Huang, YT, Chen, LM, Wong, KT, Huang, HM, Chen, CH, Chang, YJ, Huang, CC & Liu, TM 2022, 'A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges', Journal of Nanobiotechnology, 卷 20, 編號 1, 311. https://doi.org/10.1186/s12951-022-01515-5

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title = "A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges",

abstract = "The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1–1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7–50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1–3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.",

keywords = "Fluorescence imaging, Multiphoton microscopy, Near-infrared red, Optoelectronic material, Photodynamic therapy, Polymer, Theranostic",

author = "Yang, {Li Xing} and Liu, {Yu Cheng} and Cho, {Chang Hui} and Chen, {Yi Rou} and Yang, {Chan Shan} and Lu, {Yin Lin} and Zhiming Zhang and Tsai, {Yi Tseng} and Chin, {Yu Cheng} and Jiashing Yu and Pan, {Hsiu Min} and Jiang, {Wei Rou} and Chia, {Zi Chun} and Huang, {Wei Shiang} and Chiu, {Yu Lin} and Sun, {Chun Kai} and Huang, {Yu Ting} and Chen, {Li Ming} and Wong, {Ken Tsung} and Huang, {Han Min} and Chen, {Chih Hsin} and Chang, {Yuan Jay} and Huang, {Chih Chia} and Liu, {Tzu Ming}",

note = "Funding Information: This work was sponsored by the Faculty of Health Sciences, University of Macau, the internal funding of the University of Macau under MYRG2018-00070-FHS, the grants funded by The Science and Technology Development Fund, Macau SAR (File No. 122/2016/A3, 018/2017/A1, FDCT/0011/2019/AKP, 0120/2020/A3 and 0026/2021/A), the Ministry of Science and Technology, Taiwan (MOST 108-2113-M-006-012-MY3, MOST 109-2113-M-029-009, MOST 109-2327-B-009-001, MOST 109-2113-M-032-002, MOST 108-2314-B-039-007-MY3, MOST 107-2113-M-002-019-MY3, MOST 110-2731-M-006-001, MOST 110-2221-E-002-013, and MOST 110-2112-M-003-012-MY3), the Center of Applied Nanomedicine, National Cheng Kung University from the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. The authors gratefully acknowledge the use of EM000800 belonging to the Core Facility Center of National Cheng Kung University. Funding Information: This work was sponsored by the Faculty of Health Sciences, University of Macau, the internal funding of the University of Macau under MYRG2018-00070-FHS, the Grants funded by The Science and Technology Development Fund, Macau SAR (File no. 122/2016/A3, 018/2017/A1, FDCT/0011/2019/AKP, 0120/2020/A3 and 0026/2021/A), the Ministry of Science and Technology, Taiwan (MOST 108-2113-M-006-012-MY3, MOST 109-2113-M-029-009, MOST 109-2327-B-009-001, MOST 109-2113-M-032-002, MOST 108-2314-B-039-007-MY3, MOST 107-2113-M-002-019-MY3, MOST 110-2731-M-006-001, MOST 110-2221-E-002-013, and MOST 110-2112-M-003-012-MY3). Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1186/s12951-022-01515-5",

language = "English",

volume = "20",

journal = "Journal of Nanobiotechnology",

issn = "1477-3155",

publisher = "BioMed Central",

number = "1",

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TY - JOUR

T1 - A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges

AU - Yang, Li Xing

AU - Liu, Yu Cheng

AU - Cho, Chang Hui

AU - Chen, Yi Rou

AU - Yang, Chan Shan

AU - Lu, Yin Lin

AU - Zhang, Zhiming

AU - Tsai, Yi Tseng

AU - Chin, Yu Cheng

AU - Yu, Jiashing

AU - Pan, Hsiu Min

AU - Jiang, Wei Rou

AU - Chia, Zi Chun

AU - Huang, Wei Shiang

AU - Chiu, Yu Lin

AU - Sun, Chun Kai

AU - Huang, Yu Ting

AU - Chen, Li Ming

AU - Wong, Ken Tsung

AU - Huang, Han Min

AU - Chen, Chih Hsin

AU - Chang, Yuan Jay

AU - Huang, Chih Chia

AU - Liu, Tzu Ming

N1 - Funding Information: This work was sponsored by the Faculty of Health Sciences, University of Macau, the internal funding of the University of Macau under MYRG2018-00070-FHS, the grants funded by The Science and Technology Development Fund, Macau SAR (File No. 122/2016/A3, 018/2017/A1, FDCT/0011/2019/AKP, 0120/2020/A3 and 0026/2021/A), the Ministry of Science and Technology, Taiwan (MOST 108-2113-M-006-012-MY3, MOST 109-2113-M-029-009, MOST 109-2327-B-009-001, MOST 109-2113-M-032-002, MOST 108-2314-B-039-007-MY3, MOST 107-2113-M-002-019-MY3, MOST 110-2731-M-006-001, MOST 110-2221-E-002-013, and MOST 110-2112-M-003-012-MY3), the Center of Applied Nanomedicine, National Cheng Kung University from the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. The authors gratefully acknowledge the use of EM000800 belonging to the Core Facility Center of National Cheng Kung University. Funding Information: This work was sponsored by the Faculty of Health Sciences, University of Macau, the internal funding of the University of Macau under MYRG2018-00070-FHS, the Grants funded by The Science and Technology Development Fund, Macau SAR (File no. 122/2016/A3, 018/2017/A1, FDCT/0011/2019/AKP, 0120/2020/A3 and 0026/2021/A), the Ministry of Science and Technology, Taiwan (MOST 108-2113-M-006-012-MY3, MOST 109-2113-M-029-009, MOST 109-2327-B-009-001, MOST 109-2113-M-032-002, MOST 108-2314-B-039-007-MY3, MOST 107-2113-M-002-019-MY3, MOST 110-2731-M-006-001, MOST 110-2221-E-002-013, and MOST 110-2112-M-003-012-MY3). Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1–1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7–50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1–3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.

AB - The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1–1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7–50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1–3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.

KW - Fluorescence imaging

KW - Multiphoton microscopy

KW - Near-infrared red

KW - Optoelectronic material

KW - Photodynamic therapy

KW - Polymer

KW - Theranostic

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JO - Journal of Nanobiotechnology

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ER -

A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges

摘要

ASJC Scopus subject areas

UN SDG

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A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges

A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges

引用此