A theoretical study of face selectivity in the michael addition of a grignard reagent with 5-substituted-2-dicyanomethyleneadamantanes

Pei Fang Wu, I. Ting Wang, Hsiu Feng Lu, Ching Fa Yao, Ying Chieh Sun

研究成果: 雜誌貢獻期刊論文同行評審

摘要

Face selectivity for the reactions of 5-substituted (X)-2- dicyanomethyleneadamantanes with a Grignard reagent was examined using ab initio calculation for the substituents (X=F, Cl, Br, OH, NH2, and CH 3). The calculated syn/anti product ratio based, on the results of transition state energies for the halide substituents are in good agreement with the available experimental results. In addition, the results of the natural bond orbital calculation suggest that the through-bond Cieplak hyperconjugation effect, instead of the through-space interaction suggested by the experimental results in a prior study, is the main factor in determining face selectivity for the halide substituents in the present study, while for (X=OH, NH2, and CH3) substituents, other interactions may have unnegligible effects as well.

原文英語
頁(從 - 到)545-549
頁數5
期刊Journal of the Chinese Chemical Society
50
發行號3 B
DOIs
出版狀態已發佈 - 2003 一月 1

ASJC Scopus subject areas

  • 化學 (全部)

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