A Rapid Synthesis of Chiral Allylic Amines via Microwave-assisted Asymmetric Alkenylation of N-Tosyl Aldimines Catalyzed by Rhodium/Chiral Diene Complexes

Balraj Gopula, Hao Wei Zeng, Ping Yu Wu, Julian P. Henschke, Hsyueh Liang Wu

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)

摘要

A method providing expeditious access to chiral allylic amines via a Rh(I)/bicyclo[2.2.1]heptadiene-catalyzed enantioselective alkenylation of N-tosyl aldimines with potassium alkenyltrifluoroborates under microwave irradiation is described. The rate of the asymmetric 1,2-addition reaction, conducted in the presence of 1 mol % of the catalyst, was significantly enhanced as compared to when the standard heating method was applied while still providing the corresponding products without decrease in enantioselectivity.

原文英語
頁(從 - 到)312-316
頁數5
期刊Journal of the Chinese Chemical Society
65
發行號3
DOIs
出版狀態已發佈 - 2018 三月

ASJC Scopus subject areas

  • Chemistry(all)

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