A novel type of matrix for surface-assisted laser desorptioneionization mass spectrometric detection of biomolecules using metal-organic frameworks

Chien Ping Fu, Stephen Lirio, Wan Ling Liu, Chia Her Lin, Hsi Ya Huang*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

35 引文 斯高帕斯(Scopus)

摘要

A 3D metal-organic framework (MOF) nanomaterial as matrix for surface-assisted laser desorption/ ionization mass spectrometry (SALDI-MS) and tandem mass spectrometry (MS/MS) was developed for the analysis of complex biomolecules. Unlike other nanoparticle matrices, this MOF nanomaterial does not need chemical modification prior to use. An exceptional signal reproducibility as well as very low background interferences in analyzing mono-/di-saccharides, peptides and complex starch digests demonstrate its high potential for biomolecule assays, especially for small molecules.

原文英語
頁(從 - 到)103-109
頁數7
期刊Analytica Chimica Acta
888
DOIs
出版狀態已發佈 - 2015
對外發佈

ASJC Scopus subject areas

  • 分析化學
  • 生物化學
  • 環境化學
  • 光譜

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