A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis

Huey Wen Shyu, Shih Hsien Hsu, Hsiu Mei Hsieh-Li, Hung Li

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)

摘要

Members of the RING finger family are implicated in a variety of functions such as signal transduction, transcriptional regulation and other developmental processes. Using degenerate oligonucleotide primers corresponding to the RING domain, we isolated a novel RING finger gene from the mouse testis cDNA library, which was about 1.8 kb and was termed Trif (testis-specific ring finger). This deduced protein contains an N-terminal RING-finger, a B-box, and a C-terminal B-30.2-like domain, which make the Trif protein a member of the RING finger-B-box-coil-coil family. Northern blot analysis of adult multiple tissues indicated that Trif is expressed predominantly in the testis. Further analysis detected Trif transcripts in the testis from day 20 of the postnatal stage. In situ hybridization indicated that Trif is expressed in the round spermatids of the seminiferous tubules. These expression data suggest that Trif may play an important role in the regulation of spermatogenesis.

原文英語
頁(從 - 到)213-216
頁數4
期刊Mechanisms of Development
108
發行號1-2
DOIs
出版狀態已發佈 - 2001

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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