A new model for predicting the timing of leukapheresis on the basis of CD34+ cell and hematopoietic progenitor cell levels

Hao Wei Teng, Liang Tsai Hsiao, Shu Chou Chaou, Jyh Pyng Gau, Tzu Chi Lee, Ying Yih Shih, Chun Yu Liu, Ying Chung Hong, Ming Huang Chen, Mu Hsin Chang, Ya Hsu Yang, Po Min Chen*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

2 引文 斯高帕斯(Scopus)

摘要

We developed a model (depending on peripheral CD34+ cell count and hematopoietic progenitor cell count) to determine the optimal timing of 3-day leukapheresis in patients pretreated with chemotherapy and G-CSF. Marrow potentials were identified on the basis of three patterns of leukapheretic yield. Pattern 1 predicted good marrow potential. The positive predictive value of a first-day leukapheretic yield of >1 × 106 CD34 + cells/kg (mean 3-day yield = 8.18 × 106 CD34 + cells/kg, n = 11) was 100%. Pattern 2 predicted poor marrow potential. The negative predictive value of a 3-day leukapheretic yield of >1 × 106 CD34+ cells/kg (3-day yield = 0.26 × 106 CD34+ cells/kg, n = 1) was 100%. Pattern 3 met neither of the above criteria (mean 3-day yield = 1.37 × 106 CD34 + cells/kg, n = 19). The marrow potential was borderline and patients could be further divided into two subgroups according to peripheral CD34 + cell counts when WBC reached >10,000/μ1. The mean yield differed significantly between pattern 1 and 3 (P < 0.001). For patients with good marrow potential, leukapheresis should begin as soon as the WBC count is >5,000/μ1. Patients with borderline marrow potential may benefit from delaying leukapheresis until the WBC level is >10,000/μ1 and leukapheresis extended more than 3 days.

原文英語
頁(從 - 到)195-203
頁數9
期刊Journal of Clinical Apheresis
22
發行號4
DOIs
出版狀態已發佈 - 2007
對外發佈

ASJC Scopus subject areas

  • 血液學

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