A mild oxidation of 1,1-diorganometallics to ketones and aldehydes. A new stereoselective approach to aldol products part I

Paul Knochel, Chaodong Xiao, Ming Chang P. Yeh

研究成果: 雜誌貢獻文章

40 引文 斯高帕斯(Scopus)

摘要

The 1,1-diorganometallics of magnesium and zinc 1 are converted by the reaction with Me3SnCl to the 1,1-diorganometallics of tin and zinc 2 which are readily oxidized by dry air at -10° to 0°C to afford the corresponding aldehydes and ketones 3 in 57-91% yield. This mild oxidation reaction allows a new stereoselective approach to aldol products. An extension of the reaction to 1,1-diorganometallics of silicon and zinc is described.

原文英語
頁(從 - 到)6697-6700
頁數4
期刊Tetrahedron Letters
29
發行號51
DOIs
出版狀態已發佈 - 1988

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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