A kinetic-dynamic model for regulatory RNA processing

Sher Singh, Hsiu Yi Ou Yang, Mei Ying Chen, Sung Liang Yu*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

5 引文 斯高帕斯(Scopus)

摘要

A kinetic-dynamic model was proposed to simulate RNA processing by determining four essential reaction rates, including the rates of transcription, pre-mRNA turnover, pre-mRNA splicing, and mRNA decay. A family competition evolutionary algorithm (FCEA) was adapted herein to approximate these rates. Several artificial datasets were used to verify the correctness and robustness of the FCEA. The model was finally applied on time series data of yeast prp4-l mutant cells for determination of rates of RNA processing. Based on the FCEA, the model indicated that the pre-mRNA splicing was decreased in the mutant cells as well as the possible effects on transcription, pre-mRNA turnover, and mRNA decay, which was consistent with surveyed literature.

原文英語
頁(從 - 到)488-495
頁數8
期刊Journal of Biotechnology
127
發行號3
DOIs
出版狀態已發佈 - 2007 一月 10

ASJC Scopus subject areas

  • 生物技術
  • 生物工程
  • 應用微生物與生物技術

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