A genome-wide linkage scan for distinct subsets of schizophrenia characterized by age at onset and neurocognitive deficits

Yin Ju Lien, Po Chang Hsiao, Chih Min Liu, Stephen V. Faraone, Ming T. Tsuang, Hai Gwo Hwu, Wei J. Chen

    研究成果: 雜誌貢獻期刊論文同行評審

    6 引文 斯高帕斯(Scopus)

    摘要

    Background: As schizophrenia is genetically and phenotypically heterogeneous, targeting genetically informative phenotypes may help identify greater linkage signals. The aim of the study is to evaluate the genetic linkage evidence for schizophrenia in subsets of families with earlier age at onset or greater neurocognitive deficits. Methods: Patients with schizophrenia (n = 1,207) and their first-degree relatives (n = 1,035) from 557 families with schizophrenia were recruited from six data collection field research centers throughout Taiwan. Subjects completed a face-to-face semi-structured interview, the Continuous Performance Test (CPT), the Wisconsin Card Sorting Test, and were genotyped with 386 microsatellite markers across the genome. Results: A maximum nonparametric logarithm of odds (LOD) score of 4.17 at 2q22.1 was found in 295 families ranked by increasing age at onset, which had significant increases in the maximum LOD score compared with those obtained in initial linkage analyses using all available families. Based on this subset, a further subsetting by false alarm rate on the undegraded and degraded CPT obtained further increase in the nested subset-based LOD on 2q22.1, with a score of 7.36 in 228 families and 7.71 in 243 families, respectively. Conclusion: We found possible evidence of linkage on chromosome 2q22.1 in families of schizophrenia patients with more CPT false alarm rates nested within the families with younger age at onset. These results highlight the importance of incorporating genetically informative phenotypes in unraveling the complex genetics of schizophrenia.

    原文英語
    文章編號e24103
    期刊PloS one
    6
    發行號8
    DOIs
    出版狀態已發佈 - 2011 八月 29

    ASJC Scopus subject areas

    • 生物化學、遺傳與分子生物學 (全部)
    • 農業與生物科學 (全部)
    • 多學科

    指紋

    深入研究「A genome-wide linkage scan for distinct subsets of schizophrenia characterized by age at onset and neurocognitive deficits」主題。共同形成了獨特的指紋。

    引用此