A general approach to the screening and confirmation of tryptamines and phenethylamines by mass spectral fragmentation

Bo Hong Chen, Ju Tsung Liu, Wen Xiong Chen, Hung Ming Chen, Cheng Huang Lin

研究成果: 雜誌貢獻期刊論文同行評審

20 引文 斯高帕斯(Scopus)

摘要

Certain characteristic fragmentations of tryptamines (indoleethylamine) and phenethylamines are described. Based on the GC-EI/MS, LC-ESI/MS and MALDI/TOFMS, the mass fragmentations of 13 standard compounds, including α-methyltryptamine (AMT), N,N-dimethyltryptamine (DMT), 5-methoxy-α-methyltryptamine (5-MeO-AMT), N,N-diethyltryptamine (DET), N,N-dipropyltryptamine (DPT), N,N-dibutyltryptamine (DBT), N,N-diisopropyltryptamine (DIPT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT), methamphetamine (MAMP), 3,4-methylenedioxyamphetamine (3,4-MDA), 3,4-methylenedioxymethamphetamine (3,4-MDMA) and 2-methylamino-1-(3,4-methylenedioxyphenyl)butane (MBDB), were compared. As a result, the parent ions of these analytes were hard to be obtained by GC/MS whereas the protonated molecular ions can be observed clearly by means of ESI/MS and MALDI/TOFMS. Furthermore, two major characteristic fragmentations, namely and α-cleavage ([M + H]+ → [3-vinylindole]+) and β-cleavage ([M + H]+ → [CH2N+RN1RN2]), are produced when the ESI and MALDI modes are used, respectively. In the case of ESI/MS, the fragment obtained from α-cleavage is the major process. In contrast to this, in the case of MALDI/TOFMS, the major fragment is produced via β-cleavage. The ionization efficiency and fragments formed from either α- or β-cleavages are closely related to the degree of alkylation of the side chain nitrogen in both cases.

原文英語
頁(從 - 到)512-517
頁數6
期刊Talanta
74
發行號4
DOIs
出版狀態已發佈 - 2008 一月 15

ASJC Scopus subject areas

  • Analytical Chemistry

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