A fully integrated 8-channel closed-loop neural-prosthetic cmos soc for real-time epileptic seizure control

Wei Ming Chen, Herming Chiueh, Tsan Jieh Chen, Chia Lun Ho, Chi Jeng, Ming Dou Ker, Chun-Yu Lin, Ya Chun Huang, Chia Wei Chou, Tsun Yuan Fan, Ming Seng Cheng, Yue Loong Hsin, Sheng Fu Liang, Yu Lin Wang, Fu Zen Shaw, Yu Hsing Huang, Chia Hsiang Yang, Chung Yu Wu

研究成果: 雜誌貢獻文章

121 引文 斯高帕斯(Scopus)

摘要

An 8-channel closed-loop neural-prosthetic SoC is presented for real-time intracranial EEG (iEEG) acquisition, seizure detection, and electrical stimulation in order to suppress epileptic seizures. The SoC is composed of eight energy-efficient analog front-end amplifiers (AFEAs), a 10-b delta-modulated SAR ADC (DMSAR ADC), a configurable bio-signal processor (BSP), and an adaptive high-voltage-tolerant stimulator. A wireless power-and-data transmission system is also embedded. By leveraging T-connected pseudo-resistors, the high-pass (low-pass) cutoff frequency of the AFEAs can be adjusted from 0.1 to 10 Hz (0.8 to 7 kHz). The noise-efficiency factor (NEF) of the AFEA is 1.77, and the DMSAR ADC achieves an ENOB of 9.57 bits. The BSP extracts the epileptic features from time-domain entropy and frequency spectrum for seizure detection. A constant 30-μA stimulus current is delivered by closed-loop control. The acquired signals are transmitted with on-off keying (OOK) modulation at 4 Mbps over the MedRadio band for monitoring. A multi-LDO topology is adopted to mitigate the interferences across different power domains. The proposed SoC is fabricated in 0.18-μm CMOS and occupies 13.47 mm2. Verified on Long Evans rats, the proposed SoC dissipates 2.8 mW and achieves high detection accuracy (> 92%) within 0.8 s.

原文英語
文章編號6637111
頁(從 - 到)232-247
頁數16
期刊IEEE Journal of Solid-State Circuits
49
發行號1
DOIs
出版狀態已發佈 - 2014 一月 1

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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    Chen, W. M., Chiueh, H., Chen, T. J., Ho, C. L., Jeng, C., Ker, M. D., Lin, C-Y., Huang, Y. C., Chou, C. W., Fan, T. Y., Cheng, M. S., Hsin, Y. L., Liang, S. F., Wang, Y. L., Shaw, F. Z., Huang, Y. H., Yang, C. H., & Wu, C. Y. (2014). A fully integrated 8-channel closed-loop neural-prosthetic cmos soc for real-time epileptic seizure control. IEEE Journal of Solid-State Circuits, 49(1), 232-247. [6637111]. https://doi.org/10.1109/JSSC.2013.2284346