A facile and highly diastereoselective aziridination of chiral camphor N-enoylpyrazolidinones with N-aminophthalimide

K. S. Yang, K. Chen*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

39 引文 斯高帕斯(Scopus)

摘要

Reaction of various chiral camphor N-enoylpyrazolidinones 2a-g with N-aminophthalimide in the presence of lead tetraacetate in CH2Cl2 proceed smoothly afford the corresponding N-phthalimidoaziridines (3a-e, 4f-g) with excellent material yields (86-95%) at room temperature in 5 min. High levels of diastereoselectivities (up to >95:5 dr) were obtained. The solvent effect was investigated, and the auxiliary can be easily recovered in high yields under mild reaction conditions.

原文英語
頁(從 - 到)1676-1679
頁數4
期刊Journal of Organic Chemistry
66
發行號5
DOIs
出版狀態已發佈 - 2001 三月 9

ASJC Scopus subject areas

  • 有機化學

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