TY - JOUR
T1 - A Copper-Catalyzed Cascade Approach for the Synthesis of Dibenzo[b,f]1,8-naphthyridine Derivatives
AU - Villuri, Bharath Kumar
AU - Konala, Ashok
AU - Kavala, Veerababurao
AU - Kotipalli, Trimurtulu
AU - Kuo, Chun Wei
AU - Yao, Ching Fa
PY - 2017/9/18
Y1 - 2017/9/18
N2 - The synthesis of some dibenzo[b,f]-[1,8]naphthyridine derivatives in a cascade manner is reported. The reaction includes a Knovenagel condensation, the insertion of a nitrile and an alkyne into an N–H bond and an oxidation/oxidative C–C bond cleavage sequence in the presence of copper iodide. The key 1,8-naphthyridine core was constructed in a cascade manner during the course of the reaction itself which allows diverse dibenzo[b,f]-[1,8]naphthyridine derivatives to be readily prepared. (Figure presented.).
AB - The synthesis of some dibenzo[b,f]-[1,8]naphthyridine derivatives in a cascade manner is reported. The reaction includes a Knovenagel condensation, the insertion of a nitrile and an alkyne into an N–H bond and an oxidation/oxidative C–C bond cleavage sequence in the presence of copper iodide. The key 1,8-naphthyridine core was constructed in a cascade manner during the course of the reaction itself which allows diverse dibenzo[b,f]-[1,8]naphthyridine derivatives to be readily prepared. (Figure presented.).
KW - 1,8-naphthyridines
KW - aurora kinase inhibitor
KW - cascade reaction
KW - hydroamination
KW - tandem insertion
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U2 - 10.1002/adsc.201700546
DO - 10.1002/adsc.201700546
M3 - Article
AN - SCOPUS:85028949521
VL - 359
SP - 3142
EP - 3153
JO - Advanced Synthesis and Catalysis
JF - Advanced Synthesis and Catalysis
SN - 1615-4150
IS - 18
ER -