42 oligomers can seed the fibrillization of Aβ40 peptides

Yi Shan Wu, Shing Jong Huang, Meng Hsin Wu, Ling Hsien Tu, Ming Che Lee, Jerry Chun Chung Chan*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

Aggregation of Aβ40 and Aβ42 are considered as pivotal players in the pathogenic mechanism of Alzheimer's disease. In this work, we applied reverse micelles formed by sodium bis(2-ethylhexyl) sulfosuccinate (AOT) to prepare oligomeric aggregates of Aβ40 or Aβ42 peptides. The resultant globular aggregates were approximately 22 nm in diameter and they were capable to form mature fibrils upon self-aggregation. Furthermore, we found that the Aβ42 oligomeric aggregates can seed the fibrillization of Aβ40 monomers. Solid-state NMR results revealed that the Aβ40 fibrils seeded by Aβ40 or Aβ42 oligomers adopt a similar molecular structure for the residues near the C-terminus.

原文英語
頁(從 - 到)1318-1325
頁數8
期刊Journal of the Chinese Chemical Society
69
發行號8
DOIs
出版狀態已發佈 - 2022 8月

ASJC Scopus subject areas

  • 化學 (全部)

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