1,4-Additions of the highly functionalized copper reagents RCu(CN)ZnI · 2 BFP3 to trisubstituted enones. A new BF3 promoted cyclization reaction

Ming Chang P. Yeh, Paul Knochel, William M. Butler, Scott C. Berk

研究成果: 雜誌貢獻文章

50 引文 斯高帕斯(Scopus)

摘要

The new copper reagents RCu(CN)Zn I · 2 BF3 1 containing various functional groups like esters, cyanides, chlorides or enoates react with β, β′- disubstituted enones to afford the Michael adducts 4-7 in high yields (81-98%). Cyano-substituted 1,4-adducts undergo a new cyclization reaction leading to the very stable bicyclic difluoroboron enolates 11a-11c which could be converted into the bicyclic diketones 12 under mild basic conditions. The X-ray structure of 11b is reported.

原文英語
頁(從 - 到)6693-6696
頁數4
期刊Tetrahedron Letters
29
發行號51
DOIs
出版狀態已發佈 - 1988

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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