Ying-Chieh Sun

2023

A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment

Chiu, Y. J., Teng, Y. S., Chen, C. M., Sun, Y. C., Hsieh-Li, H. M., Chang, K. H. & Lee-Chen, G. J., 2023 5月, 於: Biomolecules and Therapeutics. 31, 3, p. 285-297 13 p.

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14 引文斯高帕斯（Scopus）

Using ΔK280 Tau_RD Folding Reporter Cells to Screen TRKB Agonists as Alzheimer’s Disease Treatment Strategy

Weng, Z. K., Lin, T. H., Chang, K. H., Chiu, Y. J., Lin, C. H., Tseng, P. H., Sun, Y. C., Lin, W., Lee-Chen, G. J. & Chen, C. M., 2023 2月, 於: Biomolecules. 13, 2, 219.

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2 引文斯高帕斯（Scopus）

Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity

Lin, C. H., Hsieh, Y. S., Sun, Y. C., Huang, W. H., Chen, S. L., Weng, Z. K., Lin, T. H., Wu, Y. R., Chang, K. H., Huang, H. J., Lee, G. C., Hsieh-Li, H. M. & Lee-Chen, G. J., 2023, 於: Biomolecules and Therapeutics. 31, 1, p. 127-138 12 p.

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7 引文斯高帕斯（Scopus）

2022

Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein

Lin, T. H., Chang, K. H., Chiu, Y. J., Weng, Z. K., Sun, Y. C., Lin, W., Lee-Chen, G. J. & Chen, C. M., 2022 11月, 於: International journal of molecular sciences. 23, 21, 12734.

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16 引文斯高帕斯（Scopus）

Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity

Chiu, Y. J., Lin, T. H., Chang, K. H., Lin, W., Hsieh-Li, H. M., Su, M. T., Chen, C. M., Sun, Y. C. & Lee-Chen, G. J., 2022, 於: Aging. 14, 18, p. 7568-7586 19 p.

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13 引文斯高帕斯（Scopus）

2021

Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity via Activation of TRKB Signaling in ΔK280 Tau_RD-DsRed SH-SY5Y Cells

Chiang, N. N., Lin, T. H., Teng, Y. S., Sun, Y. C., Chang, K. H., Lin, C. Y., Hsieh-Li, H. M., Su, M. T., Chen, C. M. & Lee-Chen, G. J., 2021 12月 15, 於: Frontiers in Aging Neuroscience. 13, 758895.

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22 引文斯高帕斯（Scopus）

Multi-target effects of novel synthetic coumarin derivatives protecting aβ-gfp sh-sy5y cells against aβ toxicity

Huang, C. C., Chang, K. H., Chiu, Y. J., Chen, Y. R., Lung, T. H., Hsieh-Li, H. M., Su, M. T., Sun, Y. C., Chen, C. M., Lin, W. & Lee-Chen, G. J., 2021 11月, 於: Cells. 10, 11, 3095.

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14 引文斯高帕斯（Scopus）

Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2 H -Chromen-2-One Activates CREB-Mediated Neuroprotection in A β and Tau Cell Models of Alzheimer's Disease

Chiu, Y. J., Lin, T. H., Chen, C. M., Lin, C. H., Teng, Y. S., Lin, C. Y., Sun, Y. C., Hsieh-Li, H. M., Su, M. T., Lee-Chen, G. J., Lin, W. & Chang, K. H., 2021, 於: Oxidative medicine and cellular longevity. 2021, 3058861.

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12 引文斯高帕斯（Scopus）

2020

Effective methane conversion to methanol on bi-functional graphene-oxide-supported platinum nanoclusters (Pt₅)-a DFT study

Chang, C. C., Liu, C. Y. & Sun, Y. C., 2020 3月 7, 於: Physical Chemistry Chemical Physics. 22, 9, p. 4967-4973 7 p.

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17 引文斯高帕斯（Scopus）

LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease

Fan, C. H., Lin, C. W., Huang, H. J., Lee-Chen, G. J., Sun, Y. C., Lin, W., Chen, C. M., Chang, K. H., Su, M. T. & Hsieh-Li, H. M., 2020 10月 1, 於: Psychopharmacology. 237, 10, p. 3173-3190 18 p.

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15 引文斯高帕斯（Scopus）

Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases

Chung, Y. H., Lin, C. W., Huang, H. Y., Chen, S. L., Huang, H. J., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Chang, Y. C. & Hsieh-Li, H. M., 2020 7月 1, 於: Journal of Molecular Neuroscience. 70, 7, p. 1140-1152 13 p.

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14 引文斯高帕斯（Scopus）

2019

Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

Huang, H. J., Chen, S. L., Huang, H. Y., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Hsieh-Li, H. M. & Su, M. T., 2019 2月 14, 於: Psychopharmacology. 236, 2, p. 763-773 11 p.

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15 引文斯高帕斯（Scopus）

Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease

Chiu, Y. J., Hsieh, Y. H., Lin, T. H., Lee, G. C., Hsieh-Li, H. M., Sun, Y. C., Chen, C. M., Chang, K. H. & Lee-Chen, G. J., 2019 5月, 於: Neurochemistry International. 125, p. 175-186 12 p.

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20 引文斯高帕斯（Scopus）

2018

Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell lines

Li, H. Y., Lee, J. D., Chen, C. W., Sun, Y. C. & Cheng, W. C., 2018 1月 20, 於: European Journal of Medicinal Chemistry. 144, p. 626-634 9 p.

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6 引文斯高帕斯（Scopus）

2017

Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay

Hsu, C. J., Hsu, W. C., Lee, D. J., Liu, A. L., Chang, C. M., Shih, H. J., Huang, W. H., Lee-Chen, G. J., Hsieh-Li, H. M., Lee, G. C. & Sun, Y. C., 2017 8月 1, 於: Chemical Biology and Drug Design. 90, 2, p. 272-281 10 p.

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5 引文斯高帕斯（Scopus）

2016

Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays

Lin, C. H., Hsieh, Y. S., Wu, Y. R., Hsu, C. J., Chen, H. C., Huang, W. H., Chang, K. H., Hsieh-Li, H. M., Su, M. T., Sun, Y. C., Lee, G. C. & Lee-Chen, G. J., 2016 6月 30, 於: European Journal of Pharmaceutical Sciences. 89, p. 11-19 9 p.

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27 引文斯高帕斯（Scopus）

2015

Investigation of differences in the binding affinities of two analogous ligands for untagged and tagged p38 kinase using thermodynamic integration MD simulation

Sun, Y. C., Hsu, W. C., Hsu, C. J., Chang, C. M. & Cheng, K. H., 2015 11月 1, 於: Journal of Molecular Modeling. 21, 11, 283.

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3 引文斯高帕斯（Scopus）

2014

Using thermodynamic integration MD simulation to compute relative protein-ligand binding free energy of a GSK3β kinase inhibitor and its analogs

Lee, H. C., Hsu, W. C., Liu, A. L., Hsu, C. J. & Sun, Y. C., 2014 6月, 於: Journal of Molecular Graphics and Modelling. 51, p. 37-49 13 p.

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30 引文斯高帕斯（Scopus）

2012

Computation of relative binding free energy for an inhibitor and its analogs binding with erk kinase using thermodynamic integration md simulation

Wu, K. W., Chen, P. C., Wang, J. & Sun, Y. C., 2012 10月, 於: Journal of Computer-Aided Molecular Design. 26, 10, p. 1159-1169 11 p.

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23 引文斯高帕斯（Scopus）

2011

A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways

Chen, J. Y., Tang, Y. A., Huang, S. M., Juan, H. F., Wu, L. W., Sun, Y. C., Wang, S. C., Wu, K. W., Balraj, G., Chang, T. T., Li, W. S., Cheng, H. C. & Wang, Y. C., 2011 1月 15, 於: Cancer Research. 71, 2, p. 473-483 11 p.

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110 引文斯高帕斯（Scopus）

Prediction of the binding mode between GSK3β and a peptide derived from GSKIP using molecular dynamics simulation

Tang, X. N., Lo, C. W., Chuang, Y. C., Chen, C. T., Sun, Y. C., Hong, Y. R. & Yang, C. N., 2011 7月, 於: Biopolymers. 95, 7, p. 461-471 11 p.

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16 引文斯高帕斯（Scopus）

2010

Comparative molecular field analysis of anti-tubulin agents with indole ring binding at the colchicine binding site

Lin, I. H., Hsu, C. C., Wang, S. H., Hsieh, H. P. & Sun, Y. C., 2010 2月, 於: Journal of Theoretical and Computational Chemistry. 9, 1, p. 279-291 13 p.

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1 引文斯高帕斯（Scopus）

2009

A 3D-QSAR study of celebrex-based PDK1 inhibitors using CoMFA method

Wang, W. H., Jena, N. R., Wang, Y. C. & Sun, Y. C., 2009, 於: Journal of the Chinese Chemical Society. 56, 1, p. 59-64 6 p.

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A reversible surface functionalized nanowire transistor to study protein-protein interactions

Lin, S. P., Pan, C. Y., Tseng, K. C., Lin, M. C., Chen, C. D., Tsai, C. C., Yu, S. H., Sun, Y. C., Lin, T. W. & Chen, Y. T., 2009 6月, 於: Nano Today. 4, 3, p. 235-243 9 p.

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77 引文斯高帕斯（Scopus）

Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method

Sun, Y. C., 2009, 於: Theoretical Biology and Medical Modelling. 6, 1, 13.

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8 引文斯高帕斯（Scopus）

2008

Cytotoxicity and proteomics analyses of OSU03013 in lung cancer

Tan, Y. H., Lee, K. H., Lin, T., Sun, Y. C., Hsieh-Li, H. M., Juan, H. F. & Wang, Y. C., 2008 3月 15, 於: Clinical Cancer Research. 14, 6, p. 1823-1830 8 p.

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14 引文斯高帕斯（Scopus）

Packing of transmembrane helices in bacteriorhodopsin folding: Structure and thermodynamics

Chen, C. C., Wei, C. C., Sun, Y. C. & Chen, C. M., 2008 5月, 於: Journal of Structural Biology. 162, 2, p. 237-247 11 p.

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8 引文斯高帕斯（Scopus）

2007

Examination of the folding of a short alanine-based helical peptide with salt bridges using molecular dynamics simulation

Wang, W. Z., Lin, T. & Sun, Y. C., 2007 4月 5, 於: Journal of Physical Chemistry B. 111, 13, p. 3508-3514 7 p.

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15 引文斯高帕斯（Scopus）

Molecular dynamics simulation of folding of a short helical toxin peptide

Tsai, Y. L., Chen, H. W., Lin, T., Wang, W. Z. & Sun, Y. C., 2007 6月, 於: Journal of Theoretical and Computational Chemistry. 6, 2, p. 213-221 9 p.

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3 引文斯高帕斯（Scopus）

2005

Molecular dynamics simulation of folding of a short helical peptide with many charged residues

Wei, C. C., Ho, M. H., Wang, W. H. & Sun, Y. C., 2005 10月 27, 於: Journal of Physical Chemistry B. 109, 42, p. 19980-19986 7 p.

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11 引文斯高帕斯（Scopus）

Reactions of hydrazoic acid on TiO ₂ nanoparticles: An experimental and computational study

Wang, J. H., Lin, M. C. & Sun, Y. C., 2005 3月 24, 於: Journal of Physical Chemistry B. 109, 11, p. 5133-5142 10 p.

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13 引文斯高帕斯（Scopus）

2003

A Combined Quantum Chemistry and RRKM Calculation Predicts the O( ¹D) + C₂H₆ Reaction Can Produce Water Molecule in a Collision-Free Crossed Molecular Beam Environment

Sun, Y. C., Wang, I. T., Nguyen, T. L., Lu, H. F., Yang, X. & Mebel, A. M., 2003 9月 11, 於: Journal of Physical Chemistry A. 107, 36, p. 6986-6994 9 p.

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9 引文斯高帕斯（Scopus）

A theoretical study of face selectivity in the michael addition of a grignard reagent with 5-substituted-2-dicyanomethyleneadamantanes

Wu, P. F., Wang, I. T., Lu, H. F., Yao, C. F. & Sun, Y. C., 2003, 於: Journal of the Chinese Chemical Society. 50, 3 B, p. 545-549 5 p.

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Epoxidation of Chiral Camphor N-Enoylpyrazolidinones with Methyl(trifluoromethyl)dioxirane and Urea Hydrogen Peroxide/Acid Anhydride: Reversal of Stereoselectivity

Fan, C. L., Lee, W. D., Teng, N. W., Sun, Y. C. & Chen, K., 2003 12月 12, 於: Journal of Organic Chemistry. 68, 25, p. 9816-9818 3 p.

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34 引文斯高帕斯（Scopus）

2002

Calculated energies of adsorption of non-hydrocarbon species on diamond H/C(1 1 1) surface and the abstraction energies of these species abstracted by hydrogen atoms using ab initio calculation

Lu, H. F. & Sun, Y. C., 2002 7月, 於: Diamond and Related Materials. 11, 8, p. 1560-1565 6 p.

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3 引文斯高帕斯（Scopus）

Molecular dynamics simulation of hydrogen-covered reconstructed Si(1 0 0):H-2 × 1 silicon surface: Calculation of vibrational energy relaxation rates of hydrogen stretching modes

Ho, M. H. & Sun, Y. C., 2002 9月 20, 於: Surface Science. 516, 3, p. L540-L546

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3 引文斯高帕斯（Scopus）

Self-complementarity of oligo-2-aminopyridines: A new class of hydrogen-bonded ladders

Leung, M. K., Mandal, A. B., Wang, C. C., Lee, G. H., Peng, S. M., Cheng, H. L., Her, G. R., Chao, I., Lu, H. F., Sun, Y. C., Shiao, M. Y. & Chou, P. T., 2002 4月 24, 於: Journal of the American Chemical Society. 124, 16, p. 4287-4297 11 p.

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52 引文斯高帕斯（Scopus）

2001

Calculation of hydrogen abstraction reaction on hydrogen-covered H/C(1 1 1) diamond surface abstracted by non-hydrocarbon species

Lu, H. F. & Sun, Y. C., 2001 11月 10, 於: Surface Science. 494, 1, p. L787-L792

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9 引文斯高帕斯（Scopus）

2000

Molecular dynamics simulation of hydrogen isotope-terminated silicon(111) and (110) surfaces: Calculation of vibrational energy relaxation rates of hydrogen isotope stretching modes

Sun, Y. C., Lu, H. F. & Ho, M. S., 2000 2月 18, 於: Chemical Physics Letters. 318, 1-3, p. 7-14 8 p.

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7 引文斯高帕斯（Scopus）

1999

A 500-ps molecular dynamics simulation trajectory of cardiotoxin II from Taiwan cobra venom in solution: Correlation with NMR and X-ray crystallography data

Sun, Y. C., Yang, S. F., Hwang, I. L. & Wu, T. H., 1999 4月 15, 於: Journal of Computational Chemistry. 20, 5, p. 546-562 17 p.

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2 引文斯高帕斯（Scopus）

1998

Determination of vibrational energy relaxation rates of C-H,D,T stretching modes on hydrogen, deuterium, and tritium-terminated H,D,T/C(111) and H,D,T/C(110) diamond surfaces using molecular dynamics simulation: Thermal effect

Lu, H. F., Ho, M. S., Hong, S. C., Liu, A. H., Wu, P. F. & Sun, Y. C., 1998, 於: Journal of Chemical Physics. 109, 16, p. 6898-6904 7 p.

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5 引文斯高帕斯（Scopus）

1997

Calculations of vibrational energy relaxation rates of C-H,D,T stretching modes on hydrogen-, deuterium-, and tritium-terminated H,D,T/C(111)1×1 diamond surfaces

Sun, Y. C. & Chen, J. M., 1997 9月 4, 於: Journal of Physical Chemistry B. 101, 36, p. 7082-7086 5 p.

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10 引文斯高帕斯（Scopus）

1996

Free energy calculations of the mutation of Ile96 → Ala in barnase: Contributions to the difference in stability

Sun, Y. C., Veenstra, D. L. & Kollman, P. A., 1996 3月, 於: Protein Engineering. 9, 3, p. 273-281 9 p.

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31 引文斯高帕斯（Scopus）

Vibrational energy relaxation dynamics of Si-H stretching modes on stepped H/Si(111)1 × 1 surfaces

Sun, Y. C., Gai, H. & Voth, G. A., 1996 4月 15, 於: Chemical Physics. 205, 1-2 SPEC. ISS., p. 11-22 12 p.

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11 引文斯高帕斯（Scopus）

1995

Vibrational energy relaxation dynamics of SiH stretching modes on stepped H/Si(111) 1×1 surfaces

Sun, Y. C., Gai, H. & Voth, G. A., 1995 11月 15, 於: Chemical Physics. 200, 3, p. 357-368 12 p.

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2 引文斯高帕斯（Scopus）

1994

Vibrational energy relaxation dynamics of C-H stretching modes on the hydrogen-terminated H/C(111)1x1 surface

Sun, Y. C., Gai, H. & Voth, G. A., 1994, 於: The Journal of Chemical Physics. 100, 4, p. 3247-3251 5 p.

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21 引文斯高帕斯（Scopus）

1993

Path integral calculation of hydrogen diffusion rates on metal surfaces

Sun, Y. C. & Voth, G. A., 1993, 於: The Journal of Chemical Physics. 98, 9, p. 7451-7458 8 p.

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34 引文斯高帕斯（Scopus）

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