Wen-Wei Lin

2021

Construction of indeno[1,2-b]pyrrolesviachemoselectiveN-acylation/cyclization/Wittig reaction sequence

Edukondalu, A., Vagh, S. S., Lin, T. H. & Lin, W., 2021 二月 25, 於: Chemical Communications. 57, 16, p. 2045-2048 4 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

Enantioselective Synthesis of Spiropyrazolone-Fused Cyclopenta[ c]chromen-4-ones Bearing Five Contiguous Stereocenters via (3+2) Cycloaddition

Khairnar, P. V., Su, Y. H., Edukondalu, A. & Lin, W., 2021 九月 3, 於: Journal of Organic Chemistry. 86, 17, p. 12326-12335 10 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

Multi-target effects of novel synthetic coumarin derivatives protecting aβ-gfp sh-sy5y cells against aβ toxicity

Huang, C. C., Chang, K. H., Chiu, Y. J., Chen, Y. R., Lung, T. H., Hsieh-Li, H. M., Su, M-T., Sun, Y. C., Chen, C. M., Lin, W-W. & Lee-Chen, G. J., 2021 十一月, 於: Cells. 10, 11, 3095.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

開啟存取

Organophosphane-Catalyzed Construction of Functionalized 2-Ylideneoxindoles via Direct β-Acylation

Jeng, W. C., Chien, P. C., Vagh, S. S., Edukondalu, A. & Lin, W., 2021 十二月 1, 於: Synthesis (Germany). 53, 23, p. 4409-4418 10 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

Phosphine-Catalyzed Chemoselective Reduction/Elimination/Wittig Sequence for Synthesis of Functionalized 3-Alkenyl Benzofurans

Liou, Y. C., Wang, H. W., Edukondalu, A. & Lin, W., 2021 四月 16, 於: Organic Letters. 23, 8, p. 3064-3069 6 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

2 引文斯高帕斯（Scopus）

Phosphine-mediated MBH-Type/Acyl transfer/wittig sequence for construction of functionalized furo[3,2-c]coumarins

Vagh, S. S., Hou, B. J., Edukondalu, A., Wang, P. C. & Lin, W., 2021 二月 5, 於: Organic Letters. 23, 3, p. 842-846 5 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

7 引文斯高帕斯（Scopus）

Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing

Liou, Y. C., Lin, Y. A., Wang, K., Yang, J. C., Jang, Y. J., Lin, W. & Wu, Y. C., 2021 六月 2, 於: International journal of molecular sciences. 22, 12, 6251.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

開啟存取

2020

Diversity-Oriented Synthesis of Spirocyclohexene Indane-1,3-diones and Coumarin-Fused Cyclopentanes via an Organobase-Controlled Cascade Reaction

Wang, M., Tseng, P. Y., Chi, W. J., Suresh, S., Edukondalu, A., Chen, Y. R. & Lin, W., 2020 八月 19, 於: Advanced Synthesis and Catalysis. 362, 16, p. 3407-3415 9 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

3 引文斯高帕斯（Scopus）

Diversity-Oriented Synthesis of Spiropentadiene Pyrazolones and 1 H-Oxepino[2,3- c]pyrazoles from Doubly Conjugated Pyrazolones via Intramolecular Wittig Reaction

Khairnar, P. V., Wu, C. Y., Lin, Y. F., Edukondalu, A., Chen, Y. R. & Lin, W., 2020 六月 19, 於: Organic Letters. 22, 12, p. 4760-4765 6 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

11 引文斯高帕斯（Scopus）

Enantioselective Construction of Spirooxindole-Fused Cyclopenta[c]chromen-4-ones Bearing Five Contiguous Stereocenters via a Stepwise (3+2) Cycloaddition

Vagh, S. S., Karanam, P., Liao, C. C., Lin, T. H., Liou, Y. C., Edukondalu, A., Chen, Y. R. & Lin, W., 2020 四月 17, 於: Advanced Synthesis and Catalysis. 362, 8, p. 1679-1685 7 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

10 引文斯高帕斯（Scopus）

Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer’s disease cell and mouse models

Lin, T. H., Chiu, Y. J., Lin, C. H., Lin, C. Y., Chao, C. Y., Chen, Y. C., Yang, S. M., Lin, W., Mei Hsieh-Li, H., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Chen, C. M., 2020 七月 1, 於: Aging Cell. 19, 7, ACEL13169.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

開啟存取

6 引文斯高帕斯（Scopus）

LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease

Fan, C. H., Lin, C. W., Huang, H. J., Lee-Chen, G. J., Sun, Y. C., Lin, W., Chen, C. M., Chang, K. H., Su, M. T. & Hsieh-Li, H. M., 2020 十月 1, 於: Psychopharmacology. 237, 10, p. 3173-3190 18 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

3 引文斯高帕斯（Scopus）

New Synthetic 3-Benzoyl-5-Hydroxy-2 H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPK α in SCA17 Cell Models

Chen, C. M., Chen, W. L., Yang, S. T., Lin, T. H., Yang, S. M., Lin, W., Chao, C. Y., Wu, Y. R., Chang, K. H. & Lee-Chen, G. J., 2020, 於: Oxidative medicine and cellular longevity. 2020, 3129497.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

開啟存取

1 引文斯高帕斯（Scopus）

Organophosphane-catalyzed direct β-acylation of 4-arylidene pyrazolones and 5-arylidene thiazolones with acyl chlorides

Khairnar, P. V., Su, Y. H., Chen, Y. C., Edukondalu, A., Chen, Y. R. & Lin, W., 2020 九月 4, 於: Organic Letters. 22, 17, p. 6868-6872 5 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

8 引文斯高帕斯（Scopus）

Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation

Chiu, Y. J., Lin, S. A., Chen, W. L., Lin, T. H., Lin, C. H., Yao, C. F., Lin, W., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Chen, C. M., 2020 十二月, 於: Aging. 12, 23, p. 23619-23646 28 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

3 引文斯高帕斯（Scopus）

2019

An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes

Khairnar, P. V., Lung, T. H., Lin, Y. J., Wu, C. Y., Koppolu, S. R., Edukondalu, A., Karanam, P. & Lin, W., 2019 六月 7, 於: Organic Letters. 21, 11, p. 4219-4223 5 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

29 引文斯高帕斯（Scopus）

A vinylogous Michael addition-triggered quadruple cascade reaction for the enantioselective generation of multiple quaternary stereocenters

Yang, S. M., Karanam, P., Wang, M., Jang, Y. J., Yeh, Y. S., Tseng, P. Y., Ganapuram, M. R., Liou, Y. C. & Lin, W., 2019, 於: Chemical Communications. 55, 10, p. 1398-1401 4 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

18 引文斯高帕斯（Scopus）

Organophosphane-Promoted Synthesis of Functionalized α,β-Unsaturated Alkenes and Furanones via Direct β-Acylation

Liou, Y. C., Su, Y. H., Ku, K. C., Edukondalu, A., Lin, C. K., Ke, Y. S., Karanam, P., Lee, C. J. & Lin, W., 2019 十月 18, 於: Organic Letters. 21, 20, p. 8339-8343 5 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

9 引文斯高帕斯（Scopus）

Synthesis of Functionalized Benzofurans from para-Quinone Methides via Phospha-1,6-Addition/ O-Acylation/Wittig Pathway

Liou, Y. C., Karanam, P., Jang, Y. J. & Lin, W., 2019 十月 4, 於: Organic Letters. 21, 19, p. 8008-8012 5 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

19 引文斯高帕斯（Scopus）

2018

3-Homoacyl coumarin: An all carbon 1,3-dipole for enantioselective concerted (3+2) cycloaddition

Chen, Y. R., Ganapuram, M. R., Hsieh, K. H., Chen, K. H., Karanam, P., Vagh, S. S., Liou, Y. C. & Lin, W., 2018, 於: Chemical Communications. 54, 90, p. 12702-12705 4 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

23 引文斯高帕斯（Scopus）

Diversity-oriented synthesis of chromenopyrrolidines from azomethine ylides and 2-hydroxybenzylidene indandiones via base-controlled regiodivergent (3+2) cycloaddition

Yu, J. K., Chien, H. W., Lin, Y. J., Karanam, P., Chen, Y. H. & Lin, W., 2018, 於: Chemical Communications. 54, 71, p. 9921-9924 4 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

26 引文斯高帕斯（Scopus）

Diversity-Oriented Synthesis of Furo[3,2-c]coumarins and Benzofuranyl Chromenones through Chemoselective Acylation/Wittig Reaction

Yang, S. M., Wang, C. Y., Lin, C. K., Karanam, P., Reddy, G. M., Tsai, Y. L. & Lin, W., 2018 二月 5, 於: Angewandte Chemie - International Edition. 57, 6, p. 1668-1672 5 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

25 引文斯高帕斯（Scopus）

Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection

Lee, S. Y., Chiu, Y. J., Yang, S. M., Chen, C. M., Huang, C. C., Lee-Chen, G. J., Lin, W. & Chang, K. H., 2018 十二月, 於: CNS Neuroscience and Therapeutics. 24, 12, p. 1286-1298 13 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

開啟存取

15 引文斯高帕斯（Scopus）

Strategic Exploitation of the Wittig Reaction: Facile Synthesis of Heteroaromatics and Multifunctional Olefins

Karanam, P., Reddy, G. M. & Lin, W., 2018 十二月 17, 於: Synlett. 29, 20, p. 2608-2622 15 p., st-2018-a0339-a.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

11 引文斯高帕斯（Scopus）

2017

An enantioselective cascade for simultaneous generation of five quaternary stereocenters from fully substituted enones

Yang, S. M., Reddy, G. M., Wang, T. P., Yeh, Y. S., Wang, M. & Lin, W., 2017, 於: Chemical Communications. 53, 54, p. 7649-7652 4 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

14 引文斯高帕斯（Scopus）

Chemo- and Diastereoselective Michael-Michael-Acetalization Cascade for the Synthesis of 1,3-Indandione-Fused Spiro[4.5]decan Scaffolds

Yang, S. M., Tsai, Y. L., Reddy, G. M., Möhlmann, L. & Lin, W., 2017 九月 1, 於: Journal of Organic Chemistry. 82, 17, p. 9182-9190 9 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

9 引文斯高帕斯（Scopus）

Diastereoselective Synthesis of Rauhut-Currier-Type Adducts via an Unexpected α-Addition of α,β-Unsaturated γ-Butyrolactams to Coumarin Derivatives

Yang, S. M., Madhusudhan Reddy, G., Liu, M. H., Wang, T. P., Yu, J. K. & Lin, W., 2017 一月 6, 於: Journal of Organic Chemistry. 82, 1, p. 781-789 9 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

14 引文斯高帕斯（Scopus）

Four-Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes

Chen, Y. R., Reddy, G. M., Hong, S. H., Wang, Y. Z., Yu, J. K. & Lin, W., 2017 四月 24, 於: Angewandte Chemie - International Edition. 56, 18, p. 5106-5110 5 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

22 引文斯高帕斯（Scopus）

2016

Enantioselective Synthesis of Polysubstituted Benzopyrano[3,4-c]pyrrolidine Frameworks via [3 + 2] Cycloaddition of Azomethine Ylides and Coumarin Derivatives

Chang, G. H., Wang, C. Y., Madhusudhan Reddy, G., Tsai, Y. L. & Lin, W., 2016 十月 21, 於: Journal of Organic Chemistry. 81, 20, p. 10071-10080 10 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

15 引文斯高帕斯（Scopus）

Expanding the Scope of Primary Amine Catalysis: Stereoselective Synthesis of Indanedione-Fused 2,6-Disubstituted trans-Spirocyclohexanones

Madhusudhan Reddy, G., Ko, C. T., Hsieh, K. H., Lee, C. J., Das, U. & Lin, W., 2016 三月 18, 於: Journal of Organic Chemistry. 81, 6, p. 2420-2431 12 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

28 引文斯高帕斯（Scopus）

Organocatalytic Enantioselective Synthesis of Tetrahydrofluoren-9-ones via Vinylogous Michael Addition/Henry Reaction Cascade of 1,3-Indandione-Derived Pronucleophiles

Möhlmann, L., Chang, G. H., Madhusudhan Reddy, G., Lee, C. J. & Lin, W., 2016 二月 19, 於: Organic Letters. 18, 4, p. 688-691 4 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

18 引文斯高帕斯（Scopus）

Synthesis of Functionalized Furans via Chemoselective Reduction/Wittig Reaction Using Catalytic Triethylamine and Phosphine

Lee, C. J., Chang, T. H., Yu, J. K., Madhusudhan Reddy, G., Hsiao, M. Y. & Lin, W., 2016 八月 5, 於: Organic Letters. 18, 15, p. 3758-3761 4 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

51 引文斯高帕斯（Scopus）

2015

An Enantioselective Synthesis of Substituted Cyclohexanone Derivatives with an All-Carbon Quaternary Stereocenter by Using an Organocatalytic Asymmetric Domino Double Michael Addition

Chen, C. H., Ko, C. T., Reddy, G. M., Lee, C. J. & Lin, W., 2015 八月 1, 於: European Journal of Organic Chemistry. 2015, 23, p. 5254-5265 12 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

9 引文斯高帕斯（Scopus）

Asymmetric organocatalytic synthesis of highly substituted cyclohexenols by domino double-michael reactions of 1-hydroxy-1,4-dien-3-ones and 2-alkylidenemalononitriles

Jang, Y. J., Chen, Y. S., Lee, C. J., Chen, C. H., Reddy, G. M., Ko, C. T. & Lin, W., 2015 三月, 於: European Journal of Organic Chemistry. 2015, 9, p. 2066-2074 9 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

9 引文斯高帕斯（Scopus）

Base-Catalyzed domino double michael reactions of 1-hydroxy-1,4-dien-3-ones and 2-alkylidenemalononitriles: A diastereoselective route to polysubstituted 3-alkanoyl-4-hydroxycyclohex-3-enes

Jang, Y. J., Chen, Y. S., Lee, C. J., Chen, C. H. & Lin, W., 2015 一月, 於: Synthesis (Germany). 47, 1, p. 95-107 13 p., ss-2014-h0403-op.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

開啟存取

7 引文斯高帕斯（Scopus）

Organocatalytic enantioselective direct vinylogous michael addition of α,β-unsaturated γ-butyrolactam to β-acyl acrylates and 1,2-diacylethylenes

Chen, Y. R., Das, U., Liu, M. H. & Lin, W., 2015 二月 6, 於: Journal of Organic Chemistry. 80, 3, p. 1985-1992 8 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

33 引文斯高帕斯（Scopus）

Preparation of Furo[3,2-c]coumarins from 3-Cinnamoyl-4-hydroxy-2H-chromen-2-ones and Acyl Chlorides: A Bu₃P-Mediated C-Acylation/Cyclization Sequence

Lee, C. J., Tsai, C. C., Hong, S. H., Chang, G. H., Yang, M. C., Möhlmann, L. & Lin, W., 2015 七月 13, 於: Angewandte Chemie - International Edition. 54, 29, p. 8502-8505 4 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

34 引文斯高帕斯（Scopus）

Synthesis of Multifunctional Alkenes from Substituted Acrylates and Aldehydes via Phosphine-Catalyzed Wittig Reaction

Tsai, Y. L. & Lin, W., 2015 十月 1, 於: Asian Journal of Organic Chemistry. 4, 10, p. 1040-1043 4 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

19 引文斯高帕斯（Scopus）

2014

Chemoselective intramolecular wittig reactions for the synthesis of oxazoles and benzofurans

Fan, Y. S., Das, U., Hsiao, M. Y., Liu, M. H. & Lin, W., 2014 十二月 5, 於: Journal of Organic Chemistry. 79, 23, p. 11567-11582 16 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

14 引文斯高帕斯（Scopus）

Direct β-acylation of 2-arylidene-1,3-indandiones with acyl chlorides catalyzed by organophosphanes

Lee, C. J., Sheu, C. N., Tsai, C. C., Wu, Z. Z. & Lin, W., 2014 四月 22, 於: Chemical Communications. 50, 40, p. 5304-5306 3 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

24 引文斯高帕斯（Scopus）

Synthesis of multi-functional alkenes via Wittig reaction with a new-type of phosphorus ylides

Tsai, Y. L., Syu, S. E., Yang, S. M., Das, U., Fan, Y. S., Lee, C. J. & Lin, W., 2014 八月 26, 於: Tetrahedron. 70, 34, p. 5038-5045 8 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

11 引文斯高帕斯（Scopus）

2013

An efficient organocatalytic enantioselective synthesis of spironitrocyclopropanes

Das, U., Tsai, Y. L. & Lin, W., 2013 一月 7, 於: Organic and Biomolecular Chemistry. 11, 1, p. 44-47 4 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

36 引文斯高帕斯（Scopus）

An efficient synthesis of trisubstituted oxazoles via chemoselective o-acylations and intramolecular wittig reactions

Tsai, Y. L., Fan, Y. S., Lee, C. J., Huang, C. H., Das, U. & Lin, W., 2013 十月 8, 於: Chemical Communications. 49, 87, p. 10266-10268 3 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

39 引文斯高帕斯（Scopus）

An efficient synthesis of trisubstituted oxazoles via chemoselective o-acylations and intramolecular wittig reactions

Tsai, Y. L., Fan, Y. S., Lee, C. J., Huang, C. H., Das, U. & Lin, W., 2013 十月 8, 於: Chemical Communications. 49, 87, p. 10308-10310 3 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

1 引文斯高帕斯（Scopus）

A versatile and practical method for regioselective synthesis of polysubstituted furanonaphthoquinones

Wu, Z. Z., Jang, Y. J., Lee, C. J., Lee, Y. T. & Lin, W., 2013 二月 7, 於: Organic and Biomolecular Chemistry. 11, 5, p. 828-834 7 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

17 引文斯高帕斯（Scopus）

Chemoselective synthesis of tetrasubstituted furans via intramolecular Wittig reactions: Mechanism and theoretical analysis

Lee, Y. T., Lee, Y. T., Lee, C. J., Sheu, C. N., Lin, B. Y., Wang, J. H. & Lin, W., 2013 八月 21, 於: Organic and Biomolecular Chemistry. 11, 31, p. 5156-5161 6 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

21 引文斯高帕斯（Scopus）

Enantioselective synthesis of coumarin derivatives catalyzed by primary amines

Lee, Y. T., Das, U., Chen, Y. R., Lee, C. J., Chen, C. H., Yang, M. C. & Lin, W., 2013 十一月 11, 於: Advanced Synthesis and Catalysis. 355, 16, p. 3154-3160 7 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審