Wen-Wei Lin

2025

Cascade Reactions of Enone-Tethered Ketones and Aldehydes with Indoles: Substrate-Controlled Divergent Synthesis of Indenes and Indanes

Suresh, S., Du, B. X., Lee, A., Han, X., Huang, H. M., Chiu, W., Liu, C. Y., Yao, C. F. & Lin, W., 2025 5月 23, 於: European Journal of Organic Chemistry. 28, 18, e202500097.

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Indole and Coumarin Derivatives Targeting EEF2K in Aβ Folding Reporter Cells

Chi, S. T., Wei, P. C., Chiu, Y. J., Lin, T. H., Lin, C. H., Chen, C. M., Yao, C. F., Lin, W., Lee-Chen, G. J. & Chang, K. H., 2025 1月, 於: Journal of Neurochemistry. 169, 1, e16300.

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1 引文斯高帕斯（Scopus）

2024

Coumarin-chalcone derivatives as dual NLRP1 and NLRP3 inflammasome inhibitors targeting oxidative stress and inflammation in neurotoxin-induced HMC3 and BE(2)-M17 cell models of Parkinson's disease

Lin, T. H., Chiu, Y. J., Lin, C. H., Chen, Y. R., Lin, W., Wu, Y. R., Chang, K. H., Chen, C. M. & Lee-Chen, G. J., 2024, 於: Frontiers in Aging Neuroscience. 16, 1437138.

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Diversity-oriented synthesis of chromone inden-1-one-fused cyclopentadienylides and C-acylated chromone adducts via allylic phosphorus ylides

Gurram, D. P., Marri, G., Jothimani, N., Chen, Y. R. & Lin, W., 2024 8月 9, 於: Chemical Communications. 60, 72, p. 9817-9820 4 p.

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2 引文斯高帕斯（Scopus）

Homoplantaginin Antagonizes N-Methyl-d-aspartate Receptor and Extracellular Signal-Regulated Kinase Signaling in Aβ Oligomers-Induced Neuropathology/Toxicity

Chen, T. Y., Chen, Y. R., Hsu, M. L., Liao, Y. T., Wu, C. H., Yao, C. A., Yang, W. C., Lin, W. & Lin, Y., 2024 12月 25, 於: Journal of Agricultural and Food Chemistry. 72, 51, p. 28294-28304 11 p.

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1 引文斯高帕斯（Scopus）

Investigating the therapeutic effects of novel compounds targeting inflammatory IL-1β and IL-6 signaling pathways in spinocerebellar ataxia type 3

Chen, I. C., Chen, W. L., Chang, K. H., Lee, J. W., Lin, T. H., Lin, W., Chen, C. M. & Lee-Chen, G. J., 2024 3月 15, 於: European Journal of Pharmacology. 967, 176370.

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4 引文斯高帕斯（Scopus）

Paeonol Derivative, 6′-Methyl Paeonol, Attenuates Aβ-Induced Pathophysiology in Cortical Neurons and in an Alzheimer’s Disease Mice Model

Chen, P. J., Yao, C. A., Chien, P. C., Tsai, H. J., Chen, Y. R., Chuang, J. H., Chou, P. L., Lee, G. C., Lin, W. & Lin, Y., 2024 2月 21, 於: ACS Chemical Neuroscience. 15, 4, p. 724-734 11 p.

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2 引文斯高帕斯（Scopus）

Phosphine-mediated one-pot reactions: Syntheses of β-acylated alkylidene indandiones and furo[2,3-f]dibenzotropones via MBH-type annulation/acylation or Wittig reaction

Chien, P. C., Chen, Y. J., Marri, G., Chen, Y. R., Chang, C. F., Wu, P. S. & Lin, W., 2024 12月, 於: Journal of the Chinese Chemical Society. 71, 12, p. 1482-1495 14 p.

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Small Molecules Inducing Autophagic Degradation of Expanded Polyglutamine Protein through Interaction with Both Mutant ATXN3 and LC3

Lin, T. H., Chen, W. L., Hsu, S. F., Chen, I. C., Lin, C. H., Chang, K. H., Wu, Y. R., Chen, Y. R., Yao, C. F., Lin, W., Lee-Chen, G. J. & Chen, C. M., 2024 10月, 於: International journal of molecular sciences. 25, 19, 10707.

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1 引文斯高帕斯（Scopus）

Synthesis of Furo[2,3-f]dibenzotropones via Intramolecular Wittig Reaction of Alkylidene Dibenzo-β-tropolones

Chien, P. C., Chen, Y. R., Chen, Y. J., Chang, C. F., Marri, G. & Lin, W., 2024 2月 19, 於: Advanced Synthesis and Catalysis. 366, 3, p. 420-425 6 p.

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5 引文斯高帕斯（Scopus）

The Integral Role of Conjugate Acids in Brønsted Base-Catalyzed Regiodivergent Synthesis

Chen, Y. R., Marri, G. & Lin, W., 2024 9月 23, 於: ChemCatChem. 16, 18, e202400405.

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2023

Alkylidene Meldrum′s Acid as Acceptor-Donor-Acceptor with Azomethine Ylide for Organocatalytic Asymmetric (3+2) Cycloaddition/Annulation: Synthesis of Chromeno[4,3-b]pyrrolidine

Liou, Y. C., Chen, Y. R., Hsu, C. W., Huang, X. R., Wang, H. W. & Lin, W., 2023 11月 7, 於: Advanced Synthesis and Catalysis. 365, 21, p. 3603-3610 8 p.

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3 引文斯高帕斯（Scopus）

Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity

Yang, P. N., Chen, W. L., Lee, J. W., Lin, C. H., Chen, Y. R., Lin, C. Y., Lin, W., Yao, C. F., Wu, Y. R., Chang, K. H., Chen, C. M. & Lee-Chen, G. J., 2023, 於: Aging. 15, 16, p. 8061-8089 29 p.

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4 引文斯高帕斯（Scopus）

Diversity-Oriented Synthesis of Spiro- and 3-Methylene-hydroquinoline-Indandiones via an Organobase-Controlled Cascade Strategy

Lung, T. H., Chen, Y. R., Chang, C. L., Jeng, W. C., Wu, P. S., Sambhaji Vagh, S., Marri, G., Lin, Y. F. & Lin, W., 2023 5月 12, 於: Advanced Synthesis and Catalysis. 365, 9, p. 1391-1397 7 p.

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6 引文斯高帕斯（Scopus）

Synthesis of chromeno[4,3-b]pyrrolidines from azomethine ylides and vinyl para-quinone methides via (3 + 2) cycloaddition/oxa-1,6-addition

Wu, P. S., Liou, Y. C., Marri, G., Chen, Y. R., Wu, J. R. & Lin, W., 2023 12月, 於: Journal of the Chinese Chemical Society. 70, 12, p. 2136-2146 11 p.

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1 引文斯高帕斯（Scopus）

Using ΔK280 Tau_RD Folding Reporter Cells to Screen TRKB Agonists as Alzheimer’s Disease Treatment Strategy

Weng, Z. K., Lin, T. H., Chang, K. H., Chiu, Y. J., Lin, C. H., Tseng, P. H., Sun, Y. C., Lin, W., Lee-Chen, G. J. & Chen, C. M., 2023 2月, 於: Biomolecules. 13, 2, 219.

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4 引文斯高帕斯（Scopus）

2022

Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein

Lin, T. H., Chang, K. H., Chiu, Y. J., Weng, Z. K., Sun, Y. C., Lin, W., Lee-Chen, G. J. & Chen, C. M., 2022 11月, 於: International journal of molecular sciences. 23, 21, 12734.

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19 引文斯高帕斯（Scopus）

Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity

Chiu, Y. J., Lin, T. H., Chang, K. H., Lin, W., Hsieh-Li, H. M., Su, M. T., Chen, C. M., Sun, Y. C. & Lee-Chen, G. J., 2022, 於: Aging. 14, 18, p. 7568-7586 19 p.

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14 引文斯高帕斯（Scopus）

2021

Construction of indeno[1,2-b]pyrrolesviachemoselectiveN-acylation/cyclization/Wittig reaction sequence

Edukondalu, A., Vagh, S. S., Lin, T. H. & Lin, W., 2021 2月 25, 於: Chemical Communications. 57, 16, p. 2045-2048 4 p.

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5 引文斯高帕斯（Scopus）

Enantioselective Synthesis of Spiropyrazolone-Fused Cyclopenta[ c]chromen-4-ones Bearing Five Contiguous Stereocenters via (3+2) Cycloaddition

Khairnar, P. V., Su, Y. H., Edukondalu, A. & Lin, W., 2021 9月 3, 於: Journal of Organic Chemistry. 86, 17, p. 12326-12335 10 p.

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12 引文斯高帕斯（Scopus）

Multi-target effects of novel synthetic coumarin derivatives protecting aβ-gfp sh-sy5y cells against aβ toxicity

Huang, C. C., Chang, K. H., Chiu, Y. J., Chen, Y. R., Lung, T. H., Hsieh-Li, H. M., Su, M. T., Sun, Y. C., Chen, C. M., Lin, W. & Lee-Chen, G. J., 2021 11月, 於: Cells. 10, 11, 3095.

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15 引文斯高帕斯（Scopus）

Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2 H -Chromen-2-One Activates CREB-Mediated Neuroprotection in A β and Tau Cell Models of Alzheimer's Disease

Chiu, Y. J., Lin, T. H., Chen, C. M., Lin, C. H., Teng, Y. S., Lin, C. Y., Sun, Y. C., Hsieh-Li, H. M., Su, M. T., Lee-Chen, G. J., Lin, W. & Chang, K. H., 2021, 於: Oxidative medicine and cellular longevity. 2021, 3058861.

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12 引文斯高帕斯（Scopus）

Organophosphane-Catalyzed Construction of Functionalized 2-Ylideneoxindoles via Direct β-Acylation

Jeng, W. C., Chien, P. C., Vagh, S. S., Edukondalu, A. & Lin, W., 2021 8月 16, 於: Synthesis (Germany). 53, 23, p. 4409-4418 10 p.

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1 引文斯高帕斯（Scopus）

Phosphine-Catalyzed Chemoselective Reduction/Elimination/Wittig Sequence for Synthesis of Functionalized 3-Alkenyl Benzofurans

Liou, Y. C., Wang, H. W., Edukondalu, A. & Lin, W., 2021 4月 16, 於: Organic Letters. 23, 8, p. 3064-3069 6 p.

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13 引文斯高帕斯（Scopus）

Phosphine-mediated MBH-Type/Acyl transfer/wittig sequence for construction of functionalized furo[3,2-c]coumarins

Vagh, S. S., Hou, B. J., Edukondalu, A., Wang, P. C. & Lin, W., 2021 2月 5, 於: Organic Letters. 23, 3, p. 842-846 5 p.

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28 引文斯高帕斯（Scopus）

Phosphine-Mediated Rauhut-Currier-Type/Acyl Transfer/ Wittig Strategy for Synthesis of Spirocyclopenta[c]chromene-Indolinones

Sambhaji Vagh, S., Hou, B. J., Edukondalu, A., Wang, P. C., Chen, Y. R. & Lin, W., 2021 12月 21, 於: Advanced Synthesis and Catalysis. 363, 24, p. 5429-5435 7 p.

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10 引文斯高帕斯（Scopus）

Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing

Liou, Y. C., Lin, Y. A., Wang, K., Yang, J. C., Jang, Y. J., Lin, W. & Wu, Y. C., 2021 6月 2, 於: International journal of molecular sciences. 22, 12, 6251.

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7 引文斯高帕斯（Scopus）

2020

Diversity-Oriented Synthesis of Spirocyclohexene Indane-1,3-diones and Coumarin-Fused Cyclopentanes via an Organobase-Controlled Cascade Reaction

Wang, M., Tseng, P. Y., Chi, W. J., Suresh, S., Edukondalu, A., Chen, Y. R. & Lin, W., 2020 8月 19, 於: Advanced Synthesis and Catalysis. 362, 16, p. 3407-3415 9 p.

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14 引文斯高帕斯（Scopus）

Diversity-Oriented Synthesis of Spiropentadiene Pyrazolones and 1 H-Oxepino[2,3- c]pyrazoles from Doubly Conjugated Pyrazolones via Intramolecular Wittig Reaction

Khairnar, P. V., Wu, C. Y., Lin, Y. F., Edukondalu, A., Chen, Y. R. & Lin, W., 2020 6月 19, 於: Organic Letters. 22, 12, p. 4760-4765 6 p.

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26 引文斯高帕斯（Scopus）

Enantioselective Construction of Spirooxindole-Fused Cyclopenta[c]chromen-4-ones Bearing Five Contiguous Stereocenters via a Stepwise (3+2) Cycloaddition

Vagh, S. S., Karanam, P., Liao, C. C., Lin, T. H., Liou, Y. C., Edukondalu, A., Chen, Y. R. & Lin, W., 2020 4月 17, 於: Advanced Synthesis and Catalysis. 362, 8, p. 1679-1685 7 p.

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18 引文斯高帕斯（Scopus）

Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer’s disease cell and mouse models

Lin, T. H., Chiu, Y. J., Lin, C. H., Lin, C. Y., Chao, C. Y., Chen, Y. C., Yang, S. M., Lin, W., Mei Hsieh-Li, H., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Chen, C. M., 2020 7月 1, 於: Aging Cell. 19, 7, ACEL13169.

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14 引文斯高帕斯（Scopus）

LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease

Fan, C. H., Lin, C. W., Huang, H. J., Lee-Chen, G. J., Sun, Y. C., Lin, W., Chen, C. M., Chang, K. H., Su, M. T. & Hsieh-Li, H. M., 2020 10月 1, 於: Psychopharmacology. 237, 10, p. 3173-3190 18 p.

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17 引文斯高帕斯（Scopus）

New Synthetic 3-Benzoyl-5-Hydroxy-2 H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPK α in SCA17 Cell Models

Chen, C. M., Chen, W. L., Yang, S. T., Lin, T. H., Yang, S. M., Lin, W., Chao, C. Y., Wu, Y. R., Chang, K. H. & Lee-Chen, G. J., 2020, 於: Oxidative medicine and cellular longevity. 2020, 3129497.

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6 引文斯高帕斯（Scopus）

Organophosphane-catalyzed direct β-acylation of 4-arylidene pyrazolones and 5-arylidene thiazolones with acyl chlorides

Khairnar, P. V., Su, Y. H., Chen, Y. C., Edukondalu, A., Chen, Y. R. & Lin, W., 2020 9月 4, 於: Organic Letters. 22, 17, p. 6868-6872 5 p.

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15 引文斯高帕斯（Scopus）

Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation

Chiu, Y. J., Lin, S. A., Chen, W. L., Lin, T. H., Lin, C. H., Yao, C. F., Lin, W., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Chen, C. M., 2020 12月, 於: Aging. 12, 23, p. 23619-23646 28 p.

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15 引文斯高帕斯（Scopus）

2019

An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes

Khairnar, P. V., Lung, T. H., Lin, Y. J., Wu, C. Y., Koppolu, S. R., Edukondalu, A., Karanam, P. & Lin, W., 2019 6月 7, 於: Organic Letters. 21, 11, p. 4219-4223 5 p.

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51 引文斯高帕斯（Scopus）

A vinylogous Michael addition-triggered quadruple cascade reaction for the enantioselective generation of multiple quaternary stereocenters

Yang, S. M., Karanam, P., Wang, M., Jang, Y. J., Yeh, Y. S., Tseng, P. Y., Ganapuram, M. R., Liou, Y. C. & Lin, W., 2019, 於: Chemical Communications. 55, 10, p. 1398-1401 4 p.

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32 引文斯高帕斯（Scopus）

Organophosphane-Promoted Synthesis of Functionalized α,β-Unsaturated Alkenes and Furanones via Direct β-Acylation

Liou, Y. C., Su, Y. H., Ku, K. C., Edukondalu, A., Lin, C. K., Ke, Y. S., Karanam, P., Lee, C. J. & Lin, W., 2019 10月 18, 於: Organic Letters. 21, 20, p. 8339-8343 5 p.

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16 引文斯高帕斯（Scopus）

Synthesis of Functionalized Benzofurans from para-Quinone Methides via Phospha-1,6-Addition/ O-Acylation/Wittig Pathway

Liou, Y. C., Karanam, P., Jang, Y. J. & Lin, W., 2019 10月 4, 於: Organic Letters. 21, 19, p. 8008-8012 5 p.

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31 引文斯高帕斯（Scopus）

2018

3-Homoacyl coumarin: An all carbon 1,3-dipole for enantioselective concerted (3+2) cycloaddition

Chen, Y. R., Ganapuram, M. R., Hsieh, K. H., Chen, K. H., Karanam, P., Vagh, S. S., Liou, Y. C. & Lin, W., 2018, 於: Chemical Communications. 54, 90, p. 12702-12705 4 p.

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34 引文斯高帕斯（Scopus）

Diversity-oriented synthesis of chromenopyrrolidines from azomethine ylides and 2-hydroxybenzylidene indandiones via base-controlled regiodivergent (3+2) cycloaddition

Yu, J. K., Chien, H. W., Lin, Y. J., Karanam, P., Chen, Y. H. & Lin, W., 2018, 於: Chemical Communications. 54, 71, p. 9921-9924 4 p.

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44 引文斯高帕斯（Scopus）

Diversity-Oriented Synthesis of Furo[3,2-c]coumarins and Benzofuranyl Chromenones through Chemoselective Acylation/Wittig Reaction

Yang, S. M., Wang, C. Y., Lin, C. K., Karanam, P., Reddy, G. M., Tsai, Y. L. & Lin, W., 2018 2月 5, 於: Angewandte Chemie - International Edition. 57, 6, p. 1668-1672 5 p.

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40 引文斯高帕斯（Scopus）

Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection

Lee, S. Y., Chiu, Y. J., Yang, S. M., Chen, C. M., Huang, C. C., Lee-Chen, G. J., Lin, W. & Chang, K. H., 2018 12月, 於: CNS Neuroscience and Therapeutics. 24, 12, p. 1286-1298 13 p.

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50 引文斯高帕斯（Scopus）

Strategic Exploitation of the Wittig Reaction: Facile Synthesis of Heteroaromatics and Multifunctional Olefins

Karanam, P., Reddy, G. M. & Lin, W., 2018 12月 17, 於: Synlett. 29, 20, p. 2608-2622 15 p., st-2018-a0339-a.

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19 引文斯高帕斯（Scopus）

2017

An enantioselective cascade for simultaneous generation of five quaternary stereocenters from fully substituted enones

Yang, S. M., Reddy, G. M., Wang, T. P., Yeh, Y. S., Wang, M. & Lin, W., 2017, 於: Chemical Communications. 53, 54, p. 7649-7652 4 p.

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19 引文斯高帕斯（Scopus）

Chemo- and Diastereoselective Michael-Michael-Acetalization Cascade for the Synthesis of 1,3-Indandione-Fused Spiro[4.5]decan Scaffolds

Yang, S. M., Tsai, Y. L., Reddy, G. M., Möhlmann, L. & Lin, W., 2017 9月 1, 於: Journal of Organic Chemistry. 82, 17, p. 9182-9190 9 p.

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24 引文斯高帕斯（Scopus）

Diastereoselective Synthesis of Rauhut-Currier-Type Adducts via an Unexpected α-Addition of α,β-Unsaturated γ-Butyrolactams to Coumarin Derivatives

Yang, S. M., Madhusudhan Reddy, G., Liu, M. H., Wang, T. P., Yu, J. K. & Lin, W., 2017 1月 6, 於: Journal of Organic Chemistry. 82, 1, p. 781-789 9 p.

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21 引文斯高帕斯（Scopus）

Four-Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes

Chen, Y. R., Reddy, G. M., Hong, S. H., Wang, Y. Z., Yu, J. K. & Lin, W., 2017 4月 24, 於: Angewandte Chemie - International Edition. 56, 18, p. 5106-5110 5 p.

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32 引文斯高帕斯（Scopus）

2016

Enantioselective Synthesis of Polysubstituted Benzopyrano[3,4-c]pyrrolidine Frameworks via [3 + 2] Cycloaddition of Azomethine Ylides and Coumarin Derivatives

Chang, G. H., Wang, C. Y., Madhusudhan Reddy, G., Tsai, Y. L. & Lin, W., 2016 10月 21, 於: Journal of Organic Chemistry. 81, 20, p. 10071-10080 10 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

20 引文斯高帕斯（Scopus）

Expanding the Scope of Primary Amine Catalysis: Stereoselective Synthesis of Indanedione-Fused 2,6-Disubstituted trans-Spirocyclohexanones

Madhusudhan Reddy, G., Ko, C. T., Hsieh, K. H., Lee, C. J., Das, U. & Lin, W., 2016 3月 18, 於: Journal of Organic Chemistry. 81, 6, p. 2420-2431 12 p.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

38 引文斯高帕斯（Scopus）

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